Department of Cardiology, Director Women's Cardiac Health Program, Radboud University Medical Center, Geert Grooteplein-Zuid 10, Route 616, 6525GA Nijmegen, The Netherlands.
St George's Hospitals NHS Trust University of London, Cranmer Terrace, London SW17 0RE, UK.
Eur Heart J. 2021 Mar 7;42(10):967-984. doi: 10.1093/eurheartj/ehaa1044.
Women undergo important changes in sex hormones throughout their lifetime that can impact cardiovascular disease risk. Whereas the traditional cardiovascular risk factors dominate in older age, there are several female-specific risk factors and inflammatory risk variables that influence a woman's risk at younger and middle age. Hypertensive pregnancy disorders and gestational diabetes are associated with a higher risk in younger women. Menopause transition has an additional adverse effect to ageing that may demand specific attention to ensure optimal cardiovascular risk profile and quality of life. In this position paper, we provide an update of gynaecological and obstetric conditions that interact with cardiovascular risk in women. Practice points for clinical use are given according to the latest standards from various related disciplines (Figure 1).
女性在其一生中经历重要的性激素变化,这可能会影响心血管疾病的风险。虽然传统的心血管危险因素在老年时占主导地位,但仍有一些女性特有的危险因素和炎症风险变量会影响女性在年轻和中年时的风险。妊娠高血压疾病和妊娠糖尿病与年轻女性的更高风险相关。绝经过渡期除了与衰老有关外,还会产生额外的不利影响,可能需要特别注意,以确保最佳的心血管风险状况和生活质量。在这份立场文件中,我们提供了与女性心血管风险相互作用的妇科和产科情况的最新信息。根据不同相关学科的最新标准(图 1),给出了临床应用的要点。