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Basal levels of microbiota-driven subclinical inflammation are associated with anastomotic leak in patients with colorectal cancer.

作者信息

Hajjar Roy, Fragoso Gabriela, Oliero Manon, Alaoui Ahmed Amine, Calvé Annie, Vennin Rendos Hervé, Cuisiniere Thibault, Taleb Nassima, Thérien Sophie, Dagbert François, Loungnarath Rasmy, Sebajang Herawaty, Schwenter Frank, Wassef Ramses, Ratelle Richard, Debroux Eric, Richard Carole, Santos Manuela M

机构信息

Nutrition and Microbiome Laboratory, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada

Digestive Surgery Service, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada.

出版信息

Gut. 2024 May 10;73(6):1031-1033. doi: 10.1136/gutjnl-2023-329929.

DOI:10.1136/gutjnl-2023-329929
PMID:37137685
Abstract
摘要

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Basal levels of microbiota-driven subclinical inflammation are associated with anastomotic leak in patients with colorectal cancer.微生物群驱动的亚临床炎症的基础水平与结直肠癌患者的吻合口漏相关。
Gut. 2024 May 10;73(6):1031-1033. doi: 10.1136/gutjnl-2023-329929.
2
Role of preoperative gut microbiota on colorectal anastomotic leakage: preliminary results.术前肠道微生物群对结直肠吻合口漏的作用:初步结果。
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Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines.肠道微生物通过调节粘膜促炎细胞因子影响结直肠癌手术吻合口愈合。
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引用本文的文献

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The gut microbiome and cancer: from tumorigenesis to therapy.肠道微生物群与癌症:从肿瘤发生到治疗
Nat Metab. 2025 May 6. doi: 10.1038/s42255-025-01287-w.
2
Initial gut microbiota composition is a determining factor in the promotion of colorectal cancer by oral iron supplementation: evidence from a murine model.初始肠道微生物群组成是口服铁补充剂促进结直肠癌的决定因素:来自小鼠模型的证据。
Microbiome. 2025 Apr 21;13(1):100. doi: 10.1186/s40168-025-02101-1.
3
Peroxisome proliferator-activated receptor gamma (PPAR-γ) activation through gut microbiota modulation as a novel therapeutic approach against anastomotic leak after colorectal cancer surgery.
通过调节肠道微生物群激活过氧化物酶体增殖物激活受体γ(PPAR-γ)作为结直肠癌手术后吻合口漏的一种新型治疗方法。
J Gastrointest Oncol. 2024 Oct 31;15(5):2338-2342. doi: 10.21037/jgo-24-314. Epub 2024 Oct 14.
4
Early detection of colonic anastomotic leak.结肠吻合口漏的早期检测
ANZ J Surg. 2025 Mar;95(3):277-278. doi: 10.1111/ans.19243. Epub 2024 Oct 1.
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Gut microbiota modulation: the key to improving outcomes after colorectal cancer surgery?肠道微生物群调节:改善结直肠癌手术后预后的关键?
J Gastrointest Oncol. 2024 Aug 31;15(4):1993-1995. doi: 10.21037/jgo-24-289. Epub 2024 Aug 15.
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The gut barrier as a gatekeeper in colorectal cancer treatment.肠道屏障作为结直肠癌治疗的守门员。
Oncotarget. 2024 Aug 14;15:562-572. doi: 10.18632/oncotarget.28634.