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Gut microbiota modulation: the key to improving outcomes after colorectal cancer surgery?

作者信息

Helliwell Jack A, Jayne David G

机构信息

Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.

出版信息

J Gastrointest Oncol. 2024 Aug 31;15(4):1993-1995. doi: 10.21037/jgo-24-289. Epub 2024 Aug 15.

DOI:10.21037/jgo-24-289
PMID:39279950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11399839/
Abstract
摘要

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Basal levels of microbiota-driven subclinical inflammation are associated with anastomotic leak in patients with colorectal cancer.微生物群驱动的亚临床炎症的基础水平与结直肠癌患者的吻合口漏相关。
Gut. 2024 May 10;73(6):1031-1033. doi: 10.1136/gutjnl-2023-329929.
3
Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines.
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Gut. 2023 Jun;72(6):1143-1154. doi: 10.1136/gutjnl-2022-328389. Epub 2022 Dec 30.
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Timing of Tributyrin Supplementation Differentially Modulates Gastrointestinal Inflammation and Gut Microbial Recolonization Following Murine Ileocecal Resection.丁酸盐补充时机对回肠切除术后小鼠胃肠道炎症和肠道微生物再定植的影响不同。
Nutrients. 2021 Jun 17;13(6):2069. doi: 10.3390/nu13062069.
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Exp Mol Med. 2020 Sep;52(9):1383-1396. doi: 10.1038/s12276-020-0473-2. Epub 2020 Sep 10.
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Br J Surg. 2020 May;107(6):743-755. doi: 10.1002/bjs.11388. Epub 2019 Dec 26.
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Novel de novo synthesized phosphate carrier compound ABA-PEG20k-Pi20 suppresses collagenase production in Enterococcus faecalis and prevents colonic anastomotic leak in an experimental model.新型从头合成的磷酸盐载体化合物 ABA-PEG20k-Pi20 可抑制粪肠球菌胶原酶的产生,并可预防实验性模型中的结肠吻合口漏。
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Sci Rep. 2017 Sep 6;7(1):10714. doi: 10.1038/s41598-017-11180-6.
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