Holak E J, Wu J, Spruance S L
Mycopathologia. 1986 Feb;93(2):99-104. doi: 10.1007/BF00437740.
To determine the value of serum arabinitol concentrations in clinical practice, we identified all patients at the University of Utah Medical Center for whom a serum arabinitol determination had been requested by the attending physician or housestaff to assist in the management of candidiasis. The patient population was divided into three categories on the basis of clinical and pathological findings: superficial candidiasis, possible deep, invasive candidiasis, and definite, deep invasive candidiasis. Abnormal renal function was associated with elevated concentrations of serum arabinitol in proportion to the degree of renal dysfunction. Both the serum arabinitol concentration and the arabinitol/creatinine ratio were increased in the combined patient population with candidiasis relative to normal uninfected controls (p = 0.06 and 0.001, respectively). However, neither of these tests reliably distinguished patients with invasive candidiasis from those with only superficial candidal disease.
为了确定血清阿拉伯糖醇浓度在临床实践中的价值，我们在犹他大学医学中心识别出所有被主治医生或住院医师要求测定血清阿拉伯糖醇以协助念珠菌病管理的患者。根据临床和病理结果，将患者群体分为三类：浅表念珠菌病、可能的深部侵袭性念珠菌病和确诊的深部侵袭性念珠菌病。肾功能异常与血清阿拉伯糖醇浓度升高相关，且与肾功能障碍程度成正比。与正常未感染对照组相比，念珠菌病患者合并人群的血清阿拉伯糖醇浓度和阿拉伯糖醇/肌酐比值均升高（分别为p = 0.06和0.001）。然而，这两项检测均不能可靠地区分侵袭性念珠菌病患者和仅患有浅表念珠菌病的患者。
