Wong B, Bernard E M, Gold J W, Fong D, Silber A, Armstrong D
J Infect Dis. 1982 Sep;146(3):346-52. doi: 10.1093/infdis/146.3.346.
Renal colony counts, total arabinitol appearance, and the arabinitol/creatinine ratios in the serum and urine of rats with lethal candidiasis were measured. Total arabinitol appearance and the arabinitol/creatinine ratios increased significantly after infection. The serum arabinitol/creatinine ratio was high (2 SD above the mean value in normal animals) in five of six infected rats at 24 hr, in eight of eight at 48 hr, and in none of the control animals. The urinary arabinitol/creatinine ratio was high in 14 of 19 infected rats by 24 hr, in 11 of 11 by 48 hr, and in none of the control animals. Total arabinitol appearance and the arabinitol/creatinine ratios were highly correlated with renal colony counts. Arabinitol production in vitro was sufficient to account for the increased arabinitol appearance observed in vivo in 12 of 14 rats. Thus it is concluded that the excess arabinitol that appeared in vivo was produced by the infecting fungus and that arabinitol is a quantitative marker substance for candidiasis.
对患有致死性念珠菌病的大鼠的肾菌落计数、总阿拉伯糖醇出现量以及血清和尿液中的阿拉伯糖醇/肌酐比值进行了测量。感染后，总阿拉伯糖醇出现量和阿拉伯糖醇/肌酐比值显著增加。在感染的大鼠中，6只中有5只在24小时时血清阿拉伯糖醇/肌酐比值较高（比正常动物平均值高2个标准差），8只在48小时时全部如此，而对照动物中无一例出现这种情况。到24小时时，19只感染大鼠中有14只尿液阿拉伯糖醇/肌酐比值较高，48小时时11只全部如此，对照动物中无一例出现这种情况。总阿拉伯糖醇出现量和阿拉伯糖醇/肌酐比值与肾菌落计数高度相关。体外阿拉伯糖醇产量足以解释14只大鼠中有12只体内观察到的阿拉伯糖醇出现量增加的情况。因此得出结论，体内出现的过量阿拉伯糖醇是由感染真菌产生的，并且阿拉伯糖醇是念珠菌病的一种定量标志物物质。
