γ 感觉同步化对神经退行性疾病认知功能改善的作用：机遇与挑战并存。
Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead.
作者信息
Sahu Prangya Parimita, Tseng Philip
机构信息
Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan.
Brain and Consciousness Research Center, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.
出版信息
Front Integr Neurosci. 2023 Apr 17;17:1146687. doi: 10.3389/fnint.2023.1146687. eCollection 2023.
Abstract
Neural oscillations have been categorized into various frequency bands that are mechanistically associated with different cognitive functions. Specifically, the gamma band frequency is widely implicated to be involved in a wide range of cognitive processes. As such, decreased gamma oscillation has been associated with cognitive declines in neurological diseases, such as memory dysfunction in Alzheimer's disease (AD). Recently, studies have attempted to artificially induce gamma oscillations by using 40 Hz sensory entrainment stimulation. These studies reported attenuation of amyloid load, hyper-phosphorylation of tau protein, and improvement in overall cognition in both AD patients and mouse models. In this review, we discuss the advancements in the use of sensory stimulation in animal models of AD and as a therapeutic strategy in AD patients. We also discuss future opportunities, as well as challenges, for using such strategies in other neurodegenerative and neuropsychiatric diseases.
摘要
神经振荡已被分为各种频段，这些频段在机制上与不同的认知功能相关联。具体而言，伽马频段被广泛认为参与了广泛的认知过程。因此，伽马振荡减少与神经疾病中的认知衰退有关，如阿尔茨海默病（AD）中的记忆功能障碍。最近，研究试图通过使用40赫兹的感觉夹带刺激来人工诱导伽马振荡。这些研究报告称，AD患者和小鼠模型中的淀粉样蛋白负荷减轻、tau蛋白过度磷酸化以及整体认知能力得到改善。在这篇综述中，我们讨论了在AD动物模型中使用感觉刺激作为AD患者治疗策略的进展。我们还讨论了在其他神经退行性疾病和神经精神疾病中使用此类策略的未来机遇和挑战。
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