School of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong, 643000, Sichuan, People's Republic of China.
Key Laboratory of Green Catalysis of Sichuan Institute of High Education, Sichuan University of Science and Engineering, Sichuan, 643000, Zigong, People's Republic of China.
J Biol Inorg Chem. 2023 Aug;28(5):473-483. doi: 10.1007/s00775-023-02000-6. Epub 2023 May 4.
Two novel bis-tridentate imidazole derivatives were conveniently synthesized using a 'one-pot' method. Their dinuclear (CuLCl, CuLCl) and mononuclear (CuLCl, CuLCl∙HO) copper (II) complexes were synthesized to comparably evaluate their reactivities in the hydrolytic cleavage of 2-hydroxypropyl p-nitrophenyl phosphate (HPNP) as a classic RNA model. Single crystals of CuLCl and CuLCl indicate that both of them are centrosymmetric, and each central copper ion is penta-coordinated. Regarding the transesterification of HPNP, both of dinuclear ones exhibited excess one order of magnitude rate enhancement in contrast with auto-hydrolysis reaction. Under comparable conditions, dinuclear complexes displayed no more than twofold increase in activity over their mononuclear analogues, which verifies the lack of binuclear cooperation effect due to long Cu-to-Cu space.
两种新型双齿三唑衍生物通过“一锅法”方便地合成。它们的双核（CuLCl、CuLCl）和单核（CuLCl、CuLCl·HO）铜（II）配合物被合成，以比较它们在水解断裂 2-羟丙基对硝基苯磷酸酯（HPNP）作为经典 RNA 模型中的反应活性。CuLCl 和 CuLCl 的单晶表明它们都是中心对称的，每个中心铜离子都是五配位的。对于 HPNP 的酯交换反应，与自动水解反应相比，双核配合物的反应速率均提高了一个数量级以上。在可比条件下，双核配合物的活性相对于单核类似物的增加不超过两倍，这证明由于 Cu 到 Cu 的空间较长，不存在双核协同效应。
