Inhibition of the nociceptive jaw opening reflex by the lateral reticular nucleus (LRN) in the rabbit.

The effect of stimulation of the lateral reticular nucleus (LRN) on the jaw opening reflex (JOR), evoked by tooth pulp or by palatal tissue stimulation, was studied in anesthetized rabbits. The results show an inhibitory effect on the JOR evoked by tooth pulp stimulation, which is considered a nociceptive reflex, while no effect is shown on the JOR evoked by palatal tissue stimulation. The maximum effect was observed at intervals of 30-50 ms between the two stimuli and the more effective site of inhibition in the nucleus was found to be the ventrolateral portion. The result of a selective effect of LRN stimulation on nociceptive reflexes supports the view of a role of this nucleus in the central mechanisms of pain control.