From the Hamilton Glaucoma Center (S.M., A.K., T.N., L.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
From the Hamilton Glaucoma Center (S.M., A.K., T.N., L.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Am J Ophthalmol. 2023 Aug;252:295-305. doi: 10.1016/j.ajo.2023.04.017. Epub 2023 May 2.
To evaluate the association between baseline severity of visual field (VF) damage and the initial rates of VF progression with quality of life (QOL) outcomes over an extended follow-up in glaucoma.
Retrospective cohort study.
Both eyes of 167 glaucoma or suspected glaucoma patients were followed for 10.0±0.3 years. The National Eye Institute Visual Function Questionnaire (NEI-VFQ)-25 was performed at the end of the follow-up. Separate linear regression models included the VF parameters of the better eye, the worse eye, and the central and peripheral points of the integrated binocular VF to evaluate the association of baseline and initial rates of change of VF parameters (first half of the follow-up) with NEI-VFQ-25 Rasch-calibrated disability scores over an extended follow-up.
All models demonstrated association of worse baseline severity of VF damage with worse subsequent NEI-VFQ-25 scores. Faster rates of decline in VF mean deviation of the better eye and the mean sensitivity of the central and peripheral test locations of the integrated binocular VF were significantly associated with worse subsequent NEI-VFQ-25 scores. VF parameters of the better eye performed better than those of the worse eye (R of 0.21, and 0.15, respectively), and the VF parameters of the central test locations performed better than those of the peripheral test locations (R of 0.25, and 0.20, respectively).
Baseline severity and initial rates of change of VF damage are associated with QOL outcomes over an extended follow-up. Assessment of longitudinal VF changes, especially in better eye, provides prognostic utility to identify glaucoma patients at a higher risk for developing disease-related disability.
评估青光眼患者在延长随访期间，基线视野（VF）损伤严重程度与VF 进展初始率与生活质量（QOL）结局之间的关系。
回顾性队列研究。
对 167 例青光眼或疑似青光眼患者的双眼进行了 10.0±0.3 年的随访。在随访结束时进行了国家眼科研究所视觉功能问卷（NEI-VFQ）-25 测试。单独的线性回归模型包括了较好眼、较差眼以及整合双眼 VF 的中央和周边点的 VF 参数，以评估基线和 VF 参数初始变化率（随访前半段）与延长随访期间 NEI-VFQ-25 Rasch 校准残疾评分之间的关系。
所有模型均显示，VF 损伤基线严重程度与随后的 NEI-VFQ-25 评分较差相关。较好眼的 VF 平均偏差和整合双眼 VF 的中央和周边测试位置的平均敏感度下降速度较快，与随后的 NEI-VFQ-25 评分较差显著相关。较好眼的 VF 参数比较差眼的表现更好（R 值分别为 0.21 和 0.15），而中央测试位置的 VF 参数比周边测试位置的表现更好（R 值分别为 0.25 和 0.20）。
VF 损伤的基线严重程度和初始变化率与延长随访期间的 QOL 结局相关。评估纵向 VF 变化，特别是在较好眼，为识别发生与疾病相关残疾风险较高的青光眼患者提供了预后价值。
