Ayaki Masahiko, Hanyuda Akiko, Negishi Kazuno
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Transl Vis Sci Technol. 2025 May 1;14(5):25. doi: 10.1167/tvst.14.5.25.
The aim of this study was to compare the near add power of glaucoma patients and controls between the ages of 40 and 79 years.
This was a cross-sectional study of 2724 bilateral phakic participants aged between 40 and 79 years, which included 1615 controls and 1109 patients with primary open-angle glaucoma who were using prostaglandin F (FP) receptor agonists. Participants were classified into eight age groups: 40-44, 45-49, 50-54, 55-59, 60-64, 65-69, 70-74, and 75-79 years of age. We compared the near add power and other ocular parameters between glaucoma patients and controls by age group.
There was a significant difference between glaucoma patients and controls and in spherical equivalent, intraocular pressure, cup/disc ratio, ganglion cell complex thickness, peripapillary retinal nerve fiber layer thickness, and use of dry eye eyedrops across all or many of the age groups studied. The near add power of glaucoma patients was comparable to controls of the immediately older age group until 65-69 years, indicating that the advancement of near add power of glaucoma patients was approximately five years earlier than in controls until that age range.
There was an earlier progression of presbyopia determined by near add power in glaucoma patients treated with FP receptor agonists compared with controls.
Between ages 40 and 79 years, glaucoma patients treated with prostaglandin F receptor agonists had higher near add power than controls. This knowledge could contribute to informing better management of glaucoma patients with presbyopia.
本研究旨在比较40至79岁青光眼患者与对照组的近附加光度。
这是一项对2724名年龄在40至79岁之间的双侧有晶状体参与者进行的横断面研究，其中包括1615名对照组和1109名正在使用前列腺素F（FP）受体激动剂的原发性开角型青光眼患者。参与者被分为八个年龄组：40 - 44岁、45 - 49岁、50 - 54岁、55 - 59岁、60 - 64岁、65 - 69岁、70 - 74岁和75 - 79岁。我们按年龄组比较了青光眼患者与对照组之间的近附加光度及其他眼部参数。
在所有或许多研究的年龄组中，青光眼患者与对照组在等效球镜、眼压、杯盘比、神经节细胞复合体厚度、视乳头周围视网膜神经纤维层厚度以及使用干眼眼药水方面存在显著差异。直到65 - 69岁，青光眼患者的近附加光度与紧邻的较年长年龄组的对照组相当，这表明在该年龄范围之前，青光眼患者近附加光度的进展比对照组早约五年。
与对照组相比，使用FP受体激动剂治疗的青光眼患者中，由近附加光度确定的老花眼进展更早。
在40至79岁之间，使用前列腺素F受体激动剂治疗的青光眼患者的近附加光度高于对照组。这一知识有助于为更好地管理患有老花眼的青光眼患者提供信息。
