School of Chemistry, The University of Sydney, NSW 2006, Australia; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, NSW 2006, Australia; The University of Sydney Nano Institute (Sydney Nano), The University of Sydney, NSW 2006, Australia.
Curr Opin Chem Biol. 2023 Jun;74:102311. doi: 10.1016/j.cbpa.2023.102311. Epub 2023 May 3.
While metal ions play an important role in the proper functioning of all life, many questions remain unanswered about exactly how different metals contribute to health and disease. The development of fluorescent probes, which respond to metals, has allowed greater understanding of the cellular location, concentration and speciation of metals in living systems, giving a new appreciation of their function. While the focus of studies using these fluorescent tools has largely been on mammalian organisms, there has been relatively little application of these powerful tools to other organisms. In this review, we highlight recent examples of molecular fluorophores, which have been applied to sensing metals in non-mammalian organisms.
虽然金属离子在所有生命的正常功能中起着重要作用，但对于不同的金属如何促进健康和疾病的确切机制，仍有许多问题尚未得到解答。荧光探针的发展可以响应金属，这使得人们对金属在活细胞系统中的位置、浓度和形态有了更深入的了解，从而对其功能有了新的认识。虽然这些荧光工具的研究重点主要集中在哺乳动物生物上，但这些强大工具在其他生物体中的应用相对较少。在这篇综述中，我们重点介绍了最近应用于非哺乳动物生物中金属感应的分子荧光团的例子。
