Department of Mechanical Engineering, Koç University, Sariyer, Istanbul 34450, Turkey; Koç University Translational Medicine Research Center (KUTTAM), Koç University, Istanbul 34450, Turkey.
Koç University Translational Medicine Research Center (KUTTAM), Koç University, Istanbul 34450, Turkey; Department of Biomedical Sciences and Engineering, Koç University, 34450 Istanbul, Turkey.
Trends Biotechnol. 2023 Oct;41(10):1248-1267. doi: 10.1016/j.tibtech.2023.04.001. Epub 2023 May 3.
Prostate cancer (PC) is one of the most common tumors and a leading cause of mortality among men, resulting in ~375 000 deaths annually worldwide. Various analytical methods have been designed for quantitative and rapid detection of PC biomarkers. Electrochemical (EC), optical, and magnetic biosensors have been developed to detect tumor biomarkers in clinical and point-of-care (POC) settings. Although POC biosensors have shown potential for detection of PC biomarkers, some limitations, such as the sample preparation, should be considered. To tackle such shortcomings, new technologies have been utilized for development of more practical biosensors. Here, biosensing platforms for the detection of PC biomarkers such as immunosensors, aptasensors, genosensors, paper-based devices, microfluidic systems, and multiplex high-throughput platforms, are discussed.
前列腺癌（PC）是最常见的肿瘤之一，也是男性死亡的主要原因，全球每年约有 37.5 万人因此死亡。已经设计了各种分析方法来定量和快速检测 PC 生物标志物。电化学（EC）、光学和磁生物传感器已被开发用于在临床和即时护理（POC）环境中检测肿瘤生物标志物。尽管 POC 生物传感器在检测 PC 生物标志物方面显示出了潜力，但应考虑到一些局限性，如样品制备。为了解决这些缺点，已经利用新技术开发了更实用的生物传感器。在这里，讨论了用于检测 PC 生物标志物的生物传感平台，如免疫传感器、适体传感器、基因传感器、基于纸张的设备、微流控系统和高通量多iplex 平台。
