Leibowitz S F, Shor-Posner G, Maclow C, Grinker J A
Brain Res Bull. 1986 Nov;17(5):681-9. doi: 10.1016/0361-9230(86)90200-5.
Catecholaminergic systems, specifically in the region of the lateral perifornical hypothalamus (PFH), have been linked to the inhibition of feeding behavior. The present studies examined the effects of d-amphetamine (AMPH), which is believed to act through the release of endogenous catecholamines (CAs), on spontaneous feeding and appetite regulation in rats. Injection of AMPH directly into the PFH caused a marked suppression of food intake; changes in computer-monitored meal patterns were characterized by an increase in the latency to meal onset and a consequent reduction in meal size and duration. This suggests that hypothalamic AMPH administration may influence primarily the initiation, rather than the termination, of feeding. In other experiments, chronic infusion of AMPH directly into the PFH was shown to suppress 24 hr food intake and body weight gain, indicating the effectiveness of lateral hypothalamic CA stimulation in overriding normal long-term patterns of feeding. The effect of hypothalamic CA stimulation on macronutrient selection was also investigated in groups of rats injected either centrally or peripherally with AMPH, or centrally with the CA agonists, dopamine and epinephrine. Each of these manipulations caused a strong inhibition of protein intake with no effect on carbohydrate, and only a mild suppression of fat ingestion after peripheral AMPH. These selective effects of AMPH on feeding patterns and diet choice, provide support for a role of CA innervation to the lateral hypothalamus in the modulation of natural feeding behavior and macronutrient selection.
儿茶酚胺能系统，特别是在外侧穹窿周下丘脑（PFH）区域，已被证明与进食行为的抑制有关。本研究考察了被认为通过释放内源性儿茶酚胺（CAs）起作用的右旋苯丙胺（AMPH）对大鼠自发进食和食欲调节的影响。将AMPH直接注射到PFH中会导致食物摄入量显著减少；计算机监测的进食模式变化的特点是进食开始潜伏期延长，进而导致进食量和进食持续时间减少。这表明下丘脑给予AMPH可能主要影响进食的开始，而非结束。在其他实验中，将AMPH直接慢性注入PFH被证明能抑制24小时食物摄入量和体重增加，表明外侧下丘脑CA刺激在打破正常长期进食模式方面的有效性。还对向大鼠中枢或外周注射AMPH，或向中枢注射CA激动剂多巴胺和肾上腺素的大鼠组进行了下丘脑CA刺激对常量营养素选择影响的研究。这些操作中的每一种都强烈抑制了蛋白质摄入，对碳水化合物无影响，且外周注射AMPH后仅轻微抑制了脂肪摄入。AMPH对进食模式和饮食选择的这些选择性作用，为下丘脑外侧CA神经支配在调节自然进食行为和常量营养素选择中的作用提供了支持。
