Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran.
Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
J Health Popul Nutr. 2023 May 5;42(1):39. doi: 10.1186/s41043-023-00376-4.
The evidence shows that obesity is associated with chronic inflammation in obese subjects. Polyphenols are a complex group of plant secondary metabolites that may play a role in reducing the risk of obesity and obesity-related diseases. Given the scarcity of evidence on the association between inflammatory markers and dietary polyphenols intake in overweight/obese Iranian women, the current study aims to investigate this link.
The present cross-sectional study was conducted on 391 overweight and obese Iranian women aged 18-48 years (body mass index (BMI) ≥ 25 kg/m). A 147-item food frequency questionnaire (FFQ) was used to assess dietary intake, as well as anthropometric indices including weight, height, waist circumference (WC), and hip circumference (HC) and biochemistry parameters including triglyceride (TG), total cholesterol (Chole), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), serum glutamic pyruvic transaminase (SGPT), serum glutamic-oxaloacetic transaminase (SGOT), galactin-3 (Gal-3), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor beta (TGF-β), interleukin-1 beta (IL_1β), plasminogen activator inhibitor-1 (PA-I), serum leptin concentrations, and C-reactive protein of high sensitivity (hs-CRP) in all participants. The inflammatory markers were assessed using the enzyme-linked immunosorbent assay (ELISA).
The findings revealed a significant negative association between flavonoids intake and MCP-1 (P = 0.024), lignans intake and MCP-1 (P = 0.017), and Gal-3 (P = 0.032). These significant associations were observed between other polyphenols intake and IL_1β (P = 0.014). There was also a significant positive association between other polyphenol intake and TGF-β (P = 0.008) and between phenolic acid intake and TGF-β (P = 0.014).
Our findings suggest that a high polyphenol intake may help individuals to reduce systemic inflammation. Further large studies involving participants of different ages and genders are highly warranted.
有证据表明，肥胖与肥胖人群的慢性炎症有关。多酚是一类复杂的植物次生代谢产物，可能在降低肥胖和肥胖相关疾病的风险方面发挥作用。鉴于超重/肥胖伊朗女性中炎症标志物与膳食多酚摄入量之间关联的证据有限，本研究旨在探讨这一联系。
本横断面研究纳入了 391 名年龄在 18-48 岁（体重指数（BMI）≥25kg/m）的超重和肥胖伊朗女性。使用 147 项食物频率问卷（FFQ）评估膳食摄入量，以及体重、身高、腰围（WC）和臀围（HC）等人体测量学指标，以及甘油三酯（TG）、总胆固醇（Chole）、低密度脂蛋白胆固醇（LDL-c）、高密度脂蛋白胆固醇（HDL-c）、血清谷氨酸丙酮酸转氨酶（SGPT）、血清谷氨酸草酰乙酸转氨酶（SGOT）、半乳糖凝集素-3（Gal-3）、单核细胞趋化蛋白-1（MCP-1）、转化生长因子β（TGF-β）、白细胞介素-1β（IL_1β）、纤溶酶原激活物抑制剂-1（PA-I）、血清瘦素浓度和高敏 C 反应蛋白（hs-CRP）等生化参数。使用酶联免疫吸附试验（ELISA）检测炎症标志物。
研究结果显示，黄酮类化合物摄入量与 MCP-1 之间呈显著负相关（P=0.024），木质素摄入量与 MCP-1 之间呈显著负相关（P=0.017），与 Gal-3 之间呈显著负相关（P=0.032）。其他多酚类化合物摄入量与 IL_1β 之间也存在显著正相关（P=0.014）。其他多酚类化合物摄入量与 TGF-β 之间呈显著正相关（P=0.008），酚酸摄入量与 TGF-β 之间呈显著正相关（P=0.014）。
本研究结果表明，高多酚摄入量可能有助于个体减轻全身炎症。非常需要进一步开展涉及不同年龄和性别的参与者的大型研究。
