Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
J Plast Reconstr Aesthet Surg. 2023 Jul;82:48-57. doi: 10.1016/j.bjps.2023.04.021. Epub 2023 Apr 17.
The incorporation of skin flaps in wound closure management with its cosmetic implications has appeared as a gleam of hope in providing desirable outcomes. Given the influence of extrinsic and intrinsic factors, skin flaps are prone to several complications, including ischemia-reperfusion injury (IRI). Numerous attempts have been undertaken to enhance the survival rate of skin flaps entailing pre/post-conditioning with surgical and pharmacological modalities. Various cellular and molecular mechanisms are employed in these approaches in order to reduce inflammation, promote angiogenesis and blood perfusion, and induce apoptosis and autophagy. With the emerging role of multiple stem cell lineages and their ability to improve skin flap viability, these approaches are increasingly being used to develop even more translationally applicable methods. Therefore, this review aims at providing current evidence around pharmacological interventions for improving skin flap survival and discussing their underlying mechanism of action.
皮瓣在伤口闭合管理中的应用及其美容意义，为提供理想的结果带来了一线希望。鉴于外在和内在因素的影响，皮瓣容易出现多种并发症，包括缺血再灌注损伤（IRI）。人们已经尝试了多种方法来提高皮瓣的存活率，包括手术和药物预处理。这些方法采用了各种细胞和分子机制来减少炎症、促进血管生成和血液灌注，并诱导细胞凋亡和自噬。随着多种干细胞谱系的作用不断凸显，以及它们提高皮瓣活力的能力，这些方法越来越多地被用于开发更具转化应用价值的方法。因此，本综述旨在提供改善皮瓣存活的药物干预的最新证据，并讨论其作用机制。
