一种有助于鼠伤寒血清型生物膜形成的新型小RNA的特性分析。
Characterization of a novel sRNA contributing to biofilm formation in serovar Typhimurium.
作者信息
Naaz Sayema, Sakib Najmuj, Houserova Dominika, Badve Rani, Crucello Aline, Borchert Glen M
机构信息
Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL.
出版信息
MicroPubl Biol. 2023 Apr 20;2023. doi: 10.17912/micropub.biology.000796. eCollection 2023.
Small RNAs (sRNAs) are short noncoding RNAs of ~50-200 nucleotides believed to primarily function in regulating crucial activities in bacteria during periods of cellular stress. This study examined the relevance of specific sRNAs on biofilm formation in nutrient starved serovar Typhimurium. Eight unique sRNAs were selected for deletion primarily based on their genomic location and/or putative targets. Quantitative and qualitative analyses confirm one of these, sRNA1186573, is required for efficient biofilm formation in further highlighting the significance of sRNAs during stress response.
小RNA（sRNA）是一类短的非编码RNA，长度约为50-200个核苷酸，据信主要在细胞应激期间调节细菌的关键活动。本研究考察了特定sRNA对营养饥饿的鼠伤寒血清型菌株生物膜形成的相关性。主要基于其基因组位置和/或假定靶点，选择了8种独特的sRNA进行缺失。定量和定性分析证实，其中之一sRNA1186573是高效生物膜形成所必需的，这进一步突出了sRNA在应激反应中的重要性。
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