Zhang Zhongsong, Wang Rong, Li Mao, Lu Mao
Department of Dermatovenereology, Clinical Medical College, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
School of Clinical Medicine, Chengdu Medical College, Chengdu, China.
Front Microbiol. 2025 Jun 24;16:1613315. doi: 10.3389/fmicb.2025.1613315. eCollection 2025.
Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition influenced by immune dysfunction, genetics, and environmental factors, with emerging evidence highlighting the critical role of skin and gut microbiota in its pathogenesis. This article uniquely integrates a systematic review with bibliometric analysis to map the research landscape of AD and microbiota interactions, offering a comprehensive synthesis of trends and future directions.
We conducted a bibliometric analysis using the Web of Science Core Collection, retrieving 1,196 English-language articles and reviews published between 2009 and 2024, employing a detailed search strategy targeting AD and microbiota-related terms. Data were analyzed with tools like CiteSpace, VOSviewer, and Biblioshiny to assess publication trends, geographical contributions, institutional outputs, journal impacts, author networks, reference citations, and keyword evolution.
Research on AD and microbiota has surged since 2016, peaking at 168 publications in 2021, with the USA leading in output (360 papers) and citations (24,655). The University of Copenhagen and the Journal of Allergy and Clinical Immunology emerged as top contributors, while authors like Gallo, Richard L., and Kong, Heidi H. drove influential studies. Key findings underscore the skin and gut microbiomes as research hotspots, with and the gut-skin axis dominating discussions. Emerging trends from 2020 to 2024 focus on adult AD severity, prebiotics, and personalized interventions like fecal microbiota transplantation (FMT), supported by multi omics data.
This study illuminates the dynamic growth and global collaboration in AD and microbiota research, emphasizing microbial dysbiosis and immune modulation as pivotal to AD management. These insights pave the way for precision medicine and dietary interventions, promising enhanced therapeutic strategies and improved patient outcomes through continued multidisciplinary efforts.
特应性皮炎（AD）是一种常见的慢性炎症性皮肤病，受免疫功能障碍、遗传和环境因素影响，新出现的证据突出了皮肤和肠道微生物群在其发病机制中的关键作用。本文独特地将系统综述与文献计量分析相结合，以描绘AD与微生物群相互作用的研究概况，全面综合了研究趋势和未来方向。
我们使用科学网核心合集进行文献计量分析，检索了2009年至2024年间发表的1196篇英文文章和综述，采用针对AD和微生物群相关术语的详细搜索策略。使用CiteSpace、VOSviewer和Biblioshiny等工具对数据进行分析，以评估发表趋势、地理贡献、机构产出、期刊影响力、作者网络、参考文献引用和关键词演变。
自2016年以来，关于AD和微生物群的研究激增，2021年达到168篇出版物的峰值，美国在产出（360篇论文）和引用（24655次）方面领先。哥本哈根大学和《过敏与临床免疫学杂志》成为主要贡献者，而像加洛、理查德·L.和孔、海蒂·H.等作者推动了有影响力的研究。主要发现强调皮肤和肠道微生物群是研究热点，肠道-皮肤轴主导了讨论。2020年至2024年的新趋势集中在成人AD严重程度、益生元以及粪便微生物群移植（FMT）等个性化干预措施上，这些得到了多组学数据的支持。
本研究阐明了AD和微生物群研究的动态增长和全球合作，强调微生物失调和免疫调节对AD管理至关重要。这些见解为精准医学和饮食干预铺平了道路，有望通过持续的多学科努力实现增强的治疗策略和改善患者预后。
