Popp-Snijders C, Schouten J A, van der Meer J, van der Veen E A
Scand J Clin Lab Invest. 1986 May;46(3):253-8. doi: 10.3109/00365518609083667.
The effect of a daily supplement of 75-100 g fatty fish, providing 3 g of omega 3 fatty acids, on the lipid composition and deformability of erythrocytes was studied in six healthy male subjects. After 4 weeks of the fish supplementation the mean degree of unsaturation, expressed as double bond index, of erythrocyte phosphatidyl choline (PC) and phosphatidyl ethanolamine (PE) had increased significantly by 10% and 4%, respectively. The mean cholesterol/phospholipid ratio (C/P ratio) in the membranes had increased by 28% (p less than 0.001). No change was seen in the distribution of the four major phospholipid classes. After withdrawal of the supplement for 4 weeks the changes in PC were reversed, but the changes in PE persisted and the mean C/P ratio still was higher than basal by 16% (p less than 0.01). The effect on the C/P ratio by the fatty fish is in contrast with the previously observed lack in effect of cod-liver oil. The viscosity of erythrocyte suspensions with a packed cell volume fraction of 0.80 and measured at shear rates less than or equal to 8.11 s-1 was decreased after the fish. We suggest that the fall in the viscosity of erythrocyte suspensions, reflecting increased cell deformability, is probably due to the change in the fatty acid composition of erythrocyte PC.
在六名健康男性受试者中研究了每日补充75 - 100克富含3克ω-3脂肪酸的肥鱼对红细胞脂质组成和变形能力的影响。在补充鱼类4周后，红细胞磷脂酰胆碱（PC）和磷脂酰乙醇胺（PE）的平均不饱和度（以双键指数表示）分别显著增加了10%和4%。膜中的平均胆固醇/磷脂比率（C/P比率）增加了28%（p小于0.001）。四种主要磷脂类别的分布没有变化。在停止补充4周后，PC的变化逆转，但PE的变化仍然存在，平均C/P比率仍比基础值高16%（p小于0.01）。肥鱼对C/P比率的影响与之前观察到的鱼肝油缺乏影响形成对比。在补充鱼类后，红细胞压积分数为0.80且在剪切速率小于或等于8.11 s-1下测量的红细胞悬液粘度降低。我们认为，红细胞悬液粘度的下降反映了细胞变形能力的增加，这可能是由于红细胞PC脂肪酸组成的变化。
