Kirlioglu Balcioglu Simge Seren, Zorgor Dindar Gulsah, Guclu Oya, Karabulut Nuran, Ozturk Nalan
Department of Psychiatry, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.
Department of Neurology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.
Psychiatry Res Case Rep. 2023 Jun;2(1):100115. doi: 10.1016/j.psycr.2023.100115. Epub 2023 Apr 19.
Neuropsychiatric manifestations of the COVID-19, caused by SARS-CoV-2, are under close scrutiny as the virus is shown likely to either directly or indirectly affects the central nervous system although it mainly targets the respiratory tract. Here, we describe a middle-aged male who developed acute psychiatric symptoms after a recent COVID-19 infection with no prior personal or family history of psychiatric disorder. Although there are reported cases of diagnosed psychosis or affective disorders following COVID-19 infection in the literature, to our knowledge, this is the first case where the development of autoimmune encephalitis after COVID-19 was considered and ruled out. This case report describes the comprehensive evaluation of all possible organic etiology. We also aimed to discuss possible biological underpinnings of such an exceptional comorbidity.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）的神经精神表现受到密切关注，因为尽管该病毒主要靶向呼吸道，但已显示其可能直接或间接影响中枢神经系统。在此，我们描述一名中年男性，他近期感染COVID-19后出现急性精神症状，此前无个人或家族精神病史。尽管文献中有报道COVID-19感染后诊断为精神病或情感障碍的病例，但据我们所知，这是首例考虑并排除COVID-19后发生自身免疫性脑炎的病例。本病例报告描述了对所有可能的器质性病因的综合评估。我们还旨在讨论这种特殊合并症可能的生物学基础。
