Sheppard Madeleine, Ibiebele Ibinabo, Nippita Tanya, Morris Jonathan
Faculty of Medicine and Health, Reproduction and Perinatal Centre, The University of Sydney, New South Wales, Sydney, Australia.
Kolling Institute, Northern Sydney Local Health District, New South Wales, St Leonards, Australia.
Aust N Z J Obstet Gynaecol. 2023 Oct;63(5):696-701. doi: 10.1111/ajo.13693. Epub 2023 May 8.
Asymptomatic bacteriuria (ASB) is associated with adverse maternal and neonatal outcomes and is routinely screened for and treated in the first trimester. Prevalence of ASB in the second and third trimesters of pregnancy is unknown.
The aim is to determine the prevalence of ASB in the second and third trimesters of pregnancy.
Prospective cohort study of 150 pregnant women. Mid-stream urine samples were tested for ASB in the second (24-28 ) and third (32-36 ) trimesters. Women were assigned to one of two groups: (i) ASB in any trimester of pregnancy and (ii) no evidence of ASB in pregnancy. Maternal and neonatal outcomes were compared between groups.
Among 143 women included in the study, the rate of ASB was 4.9% (2.1, 2.1 and 3.2% in the first, second and third trimesters, respectively). Of those with ASB, 14% had it in every trimester, whereas 43% had it on two or more samples. Of those with ASB in pregnancy, 43% were detected for the first time in the third trimester. Rates of maternal and neonatal outcomes were not statistically significantly different between the two groups. No women with ASB were induced for chorioamnionitis or growth restriction.
The rate of ASB was highest in the third trimester of pregnancy, with rates of 2.1, 2.1 and 3.2% in the first, second and third trimesters, respectively. This study was underpowered to assess maternal and fetal outcomes. Although numbers were small, the absence of ASB in the first trimester was a poor predictor of ASB in the third trimester.
无症状菌尿（ASB）与不良母婴结局相关，在孕早期需常规筛查和治疗。妊娠中晚期ASB的患病率尚不清楚。
确定妊娠中晚期ASB的患病率。
对150名孕妇进行前瞻性队列研究。在妊娠中期（24 - 28周）和晚期（32 - 36周）采集中段尿样本检测ASB。将女性分为两组：（i）孕期任何阶段有ASB；（ii）孕期无ASB证据。比较两组的母婴结局。
纳入研究的143名女性中，ASB发生率为4.9%（孕早期、中期和晚期分别为2.1%、2.1%和3.2%）。在有ASB的女性中，14%在每个孕期都有，而43%在两个或更多样本中检测到。在孕期有ASB的女性中，43%是在孕晚期首次检测到的。两组母婴结局发生率在统计学上无显著差异。没有因绒毛膜羊膜炎或生长受限而引产的ASB女性。
妊娠晚期ASB发生率最高，孕早期、中期和晚期分别为2.1%、2.1%和3.2%。本研究评估母婴结局的能力不足。尽管样本量小，但孕早期无ASB并不能很好地预测孕晚期是否有ASB。
