Meier J, Theakston R D
Toxicon. 1986;24(4):395-401. doi: 10.1016/0041-0101(86)90199-6.
A method is described for the assessment of lethal toxicity of venoms using a modified LD50 assay. With this test it is possible to obtain an LD50 using only 8-10 experimental animals, instead of 30 or more. It is suggested for ethical, scientific and economic reasons that this method be tested in laboratories involved in screening of venoms for lethality and, if found satisfactory, it should replace the classical LD50 assay.
描述了一种使用改良的半数致死量（LD50）测定法评估毒液致死毒性的方法。通过该测试，仅使用8 - 10只实验动物就有可能获得LD50，而不是30只或更多。出于伦理、科学和经济原因，建议在参与毒液致死性筛查的实验室中对该方法进行测试，如果结果令人满意，它应取代传统的LD50测定法。
