Departments of Statistics, Ecology and Evolution, Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, 60637, USA.
Institute for Problems in Mechanical Engineering, Russian Academy of Sciences, Saint Petersburg, 199178, Russia.
Sci Rep. 2023 May 9;13(1):7482. doi: 10.1038/s41598-023-34041-x.
This research illustrates that complex dynamics of gene products enable the creation of any prescribed cellular differentiation patterns. These complex dynamics can take the form of chaotic, stochastic, or noisy chaotic dynamics. Based on this outcome and previous research, it is established that a generic open chemical reactor can generate an exceptionally large number of different cellular patterns. The mechanism of pattern generation is robust under perturbations and it is based on a combination of Turing's machines, Turing instability and L. Wolpert's gradients. These results can help us to explain the formidable adaptive capacities of biochemical systems.
本研究表明,基因产物的复杂动力学能够创造出任何预定的细胞分化模式。这些复杂的动力学可以表现为混沌、随机或噪声混沌动力学。基于这一结果和先前的研究,可以确定通用的开放化学反应器可以产生大量不同的细胞模式。模式生成的机制在受到干扰时具有鲁棒性,它基于图灵机、图灵不稳定性和 L. 沃尔珀特梯度的组合。这些结果可以帮助我们解释生化系统令人敬畏的适应能力。