Chemistry Institute, Brazilian Doping Control Laboratory - LBCD - LADETEC, Federal University of Rio de Janeiro - UFRJ, Rio de Janeiro, Brazil.
Drug Test Anal. 2024 Jan;16(1):38-48. doi: 10.1002/dta.3517. Epub 2023 May 18.
Dietary supplements (DS) are intended for healthy people to maintain or improve their overall health. Its consumption is widespread in large part of the general population and at all levels of athletes. Nevertheless, DS use can also pose health risks to individuals and, in the case of athletes, may lead to adverse analytical findings (AAFs) due to the possibility of DS contamination or adulteration with doping agents banned by the World Anti-Doping Agency. Although educational initiatives are being performed in Brazil to warn the sports community about inadvertent doping cases, AAFs connected to the DS administration have been increasingly growing. The findings of DS analyzed by the Brazilian Doping Control Laboratory (LBCD), between 2017 and 2022, after Testing Authorities (TAs) analysis requests, showed an alarming number of tainted samples. Diuretics were the most common adulterants found in all supplement types. However, the profile of prohibited substances in manufactured and compounded dietary supplements (MDS and CDS, respectively) were distinct, with stimulants being most prevalent in MDS and anabolic agents in CDS products. Additionally, MDS samples generally presented higher estimated concentrations of banned substances (mg/g) than CDS samples (μg/g). The common practice of DS intake by athletes continues to be of great concern for a doping-free sport, given the high prevalence of prohibited substances detected in the analyzed samples by the LBCD. The current Brazilian scenario reinforces the importance of raising awareness in the sports community of the possible consequences of an unintentional doping case linked to DS use.
膳食补充剂（DS）旨在供健康人群使用，以维持或改善其整体健康状况。其消费在很大程度上在普通人群中普及，并在各级运动员中广泛存在。然而，DS 的使用也可能对个人健康造成风险，并且在运动员的情况下，由于 DS 可能受到污染或掺杂禁用兴奋剂，可能导致出现不良分析结果（AAFs）。尽管巴西正在开展教育活动，以警告体育界注意意外兴奋剂案例，但与 DS 管理相关的 AAFs 却在不断增加。巴西兴奋剂检测实验室（LBCD）在测试机构（TA）分析请求后，对 2017 年至 2022 年期间分析的 DS 进行了研究，发现了令人震惊的污染样本数量。利尿剂是所有补充剂类型中最常见的掺杂物。然而，在制成和复合膳食补充剂（MDS 和 CDS）中发现的违禁物质特征不同，兴奋剂在 MDS 中最为普遍，而合成代谢剂在 CDS 产品中更为常见。此外，MDS 样本中禁用物质的估计浓度（mg/g）通常高于 CDS 样本（μg/g）。鉴于 LBCD 分析的样本中检测到高比例的违禁物质，运动员普遍存在 DS 摄入的情况，这对无兴奋剂运动仍然是一个极大的关注。巴西目前的情况强调了在体育界提高对与 DS 使用相关的意外兴奋剂案例可能后果的认识的重要性。
