海松烷二萜类化合物：化学与药理活性。

Cembrane diterpenoids: Chemistry and pharmacological activities.

机构信息

Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.

Institute of Structural Pharmacology & TCM Chemical Biology, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.

出版信息

Phytochemistry. 2023 Aug;212:113703. doi: 10.1016/j.phytochem.2023.113703. Epub 2023 May 8.

DOI:10.1016/j.phytochem.2023.113703

PMID:37164145

Abstract

Cembrane diterpenoids (cembranoids), characterized by a 14-membered carbon ring and wide variety of functional groups, found in marine and terrestrial organisms. Many studies have shown that cembrane diterpenoids have cytotoxic and anti-inflammatory activities and are widely used in the development of new drugs. This review covered publications from 2011 to 2022 and classified the cembrane-type diterpenoids into isopropyl (ene) type, γ-lactone or unsaturated five-membered ring, δ-lactone or unsaturated six-membered ring, ε-lactone or unsaturated seven-membered ring, and other cembrane diterpenes. In addition, the biological activity and structure-activity relationship were summarized. This will provide guidance for new cembrane-type diterpenes as lead compounds to explore their potential application for treating cancer and inflammatory diseases.

摘要

海松烷二萜类（cembranoids），以 14 元碳环和广泛的官能团为特征，存在于海洋和陆地生物中。许多研究表明，海松烷二萜类具有细胞毒性和抗炎活性，并广泛用于新药的开发。本综述涵盖了 2011 年至 2022 年的出版物，并将海松烷型二萜类化合物分为异丙基（ene）型、γ-内酯或不饱和五元环、δ-内酯或不饱和六元环、ε-内酯或不饱和七元环和其他海松烷二萜类。此外，还总结了生物活性和结构-活性关系。这将为新型海松烷型二萜类化合物作为先导化合物提供指导，以探索其在治疗癌症和炎症性疾病方面的潜在应用。