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SARS-CoV-2 空气传播感染爆发报告:流行病学和分子证据。

Outbreak report of SARS-CoV-2 infection by airborne transmission: Epidemiologic and molecular evidence.

机构信息

Grupo Gastrohepatología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

出版信息

Biomedica. 2023 Mar 30;43(1):121-130. doi: 10.7705/biomedica.6695.

Abstract

INTRODUCTION

It has been shown that the transmission of SARS-CoV-2 occurs mainly by air, and the risk of infection is greater in closed spaces.

OBJECTIVE

To describe the epidemiology, virology and molecular characterization of a COVID-19 outbreak at a closed vaccination point during the third wave of SARS-CoV-2 in Colombia.

MATERIALS AND METHODS

Diagnostic tests, interviews, sampling, cell cultures and viral sequencing were carried out, the latter being molecular characterization and lineage identification.

RESULTS

Seven workers were positive for SARS-CoV-2; among these, 3 samples were analyzed, plus an additional sample belonging to the mother of the presumed index case; all samples were identified with lineage B.1.625, with a maximum of 2 nucleotides difference between them.

CONCLUSIONS

Variant B.1.625 was identified as the cause of the COVID-19 outbreak, and a co-worker was also identified as the index case. Unexpectedly, attending a vaccination day became a risk factor for acquiring the infection.

摘要

简介

已有研究表明,SARS-CoV-2 主要通过空气传播,在封闭空间中感染风险更大。

目的

描述哥伦比亚第三波 SARS-CoV-2 期间,在一个封闭疫苗接种点发生的 COVID-19 疫情的流行病学、病毒学和分子特征。

材料和方法

开展了诊断检测、访谈、采样、细胞培养和病毒测序,后者为分子特征和谱系鉴定。

结果

7 名工作人员的 SARS-CoV-2 检测结果呈阳性;其中,分析了 3 个样本,外加一个疑似指数病例母亲的额外样本;所有样本均鉴定为谱系 B.1.625,它们之间最多有 2 个核苷酸差异。

结论

B.1.625 变异株被确定为 COVID-19 疫情的起因,一名同事也被确定为指数病例。出乎意料的是,参加疫苗接种日成为感染的一个风险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/451a/10501502/438d88f0e736/2590-7379-bio-43-01-6695-gf1.jpg

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