褪黑素对幼鼠的抗糖皮质激素作用。

Anti-glucocorticoid effects of melatonin in young rats.

作者信息

Aoyama H, Mori W, Mori N

出版信息

Acta Pathol Jpn. 1986 Mar;36(3):423-8. doi: 10.1111/j.1440-1827.1986.tb01031.x.

DOI:10.1111/j.1440-1827.1986.tb01031.x

Abstract

Administration of the pineal hormone melatonin to young female rats provided significant prevention of the injurious effects (decrease of body weight gain, atrophy of the thymus and adrenals, glucosuria, elevation of the blood level of glucose, free fatty acid, triglyceride, and total cholesterol) caused by three different glucocorticoids, i.e. dexamethasone, prednisolone, and hydrocortisone. Although these protective effects of melatonin were slightly more remarkable in dexamethasone-treated rats than in prednisolone- or hydrocortisone-treated rats, our hypothesis of melatonin's anti-glucocorticoid effects is said to have been confirmed rather universally and with a considerably wide range through this experiment.

摘要

给幼年雌性大鼠注射松果体激素褪黑素，可显著预防由三种不同糖皮质激素，即地塞米松、泼尼松龙和氢化可的松所引起的有害影响（体重增加减少、胸腺和肾上腺萎缩、糖尿、血糖、游离脂肪酸、甘油三酯和总胆固醇血水平升高）。尽管褪黑素的这些保护作用在用地塞米松处理的大鼠中比在用泼尼松龙或氢化可的松处理的大鼠中略为显著，但通过该实验，我们关于褪黑素抗糖皮质激素作用的假说被认为已在相当广泛的范围内得到了较为普遍的证实。