Martin Natalie G, Roberts Amin J, Evans Helen M, Bishop Jonathan, Day Andrew S
From the Department of Paediatrics, University of Otago Christchurch, Christchurch, New Zealand.
Department of Paediatric Gastroenterology, Starship Child Health, Auckland, New Zealand.
JPGN Rep. 2022 Oct 25;3(4):e266. doi: 10.1097/PG9.0000000000000266. eCollection 2022 Nov.
New Zealand (NZ) guidelines for the approach to diagnosis and management of inflammatory bowel disease (IBD) in children were developed in 2014.
This study aimed to assess the application of the guidelines in a group of children diagnosed with IBD in regards to baseline investigations.
This retrospective observational study analyzed the application of recommended baseline investigations included in the NZ guidelines in a group of children aged <16 years diagnosed consecutively with IBD at the 2 NZ tertiary pediatric gastroenterology centers.
Fifty children were included from each center. Seventy-two were diagnosed with Crohn's disease (CD), 15 with ulcerative colitis (UC), and 13 were with IBD unclassified. The children with CD had a mean Pediatric Crohn's Disease Activity Index score of 31 and almost half had ileocolonic involvement (47%). The 15 children with UC had a mean PUCAI score of 42, and 13 had pancolonic involvement. All 100 children underwent upper and lower gastrointestinal endoscopy with biopsies, and 92% had magnetic resonance enterography at diagnosis. Iron studies, folate, and vitamin B12 were measured in >70 children. Serum zinc, magnesium, and phosphate were infrequently measured. Current anthropometry was recorded in all children but historical growth data were variably recorded. Vaccination status was also inconsistently recorded.
Most of this group of children diagnosed with IBD in 2 NZ centers underwent key recommended investigations at diagnosis including gastrointestinal endoscopy and small bowel imaging. Other baseline assessments, including measurement of micronutrient levels, were completed variably. Measures to enhance consistent baseline assessments are required.
2014年制定了新西兰儿童炎症性肠病(IBD)诊断和管理方法指南。
本研究旨在评估该指南在一组诊断为IBD的儿童中关于基线检查的应用情况。
这项回顾性观察研究分析了新西兰指南中推荐的基线检查在两个新西兰三级儿科胃肠病中心连续诊断为IBD的一组16岁以下儿童中的应用情况。
每个中心纳入了50名儿童。72例诊断为克罗恩病(CD),15例为溃疡性结肠炎(UC),13例为未分类的IBD。CD患儿的儿童克罗恩病活动指数平均评分为31,近一半患儿有回结肠受累(47%)。15例UC患儿的儿童溃疡性结肠炎活动指数平均评分为42,13例有全结肠受累。所有100名儿童均接受了上下消化道内镜检查及活检,92%在诊断时进行了磁共振小肠造影。超过70名儿童检测了铁代谢指标、叶酸和维生素B12。血清锌、镁和磷酸盐检测较少。所有儿童均记录了当前人体测量数据,但历史生长数据记录不一。疫苗接种状况记录也不一致。
在新西兰两个中心诊断为IBD的这组儿童中,大多数在诊断时接受了关键的推荐检查,包括胃肠内镜检查和小肠成像。其他基线评估,包括微量营养素水平测量,完成情况不一。需要采取措施加强一致的基线评估。