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2015年新西兰儿童炎症性肠病的前瞻性发病率:新西兰儿童炎症性肠病(PINZ)研究结果

Prospective Incidence of Paediatric Inflammatory Bowel Disease in New Zealand in 2015: Results From the Paediatric Inflammatory Bowel Disease in New Zealand (PINZ) Study.

作者信息

Lopez Robert N, Evans Helen M, Appleton Laura, Bishop Jonathan, Chin Simon, Mouat Stephen, Gearry Richard B, Day Andrew S

机构信息

Department of Paediatrics, University of Otago, Christchurch, Christchurch.

Department of Paediatric Gastroenterology, Starship Children's Hospital, Auckland.

出版信息

J Pediatr Gastroenterol Nutr. 2018 May;66(5):e122-e126. doi: 10.1097/MPG.0000000000001806.

Abstract

BACKGROUND

The global incidence of paediatric inflammatory bowel disease (IBD) is increasing. Much of the evidence attesting to this has arisen from North America and Europe. There is a relative paucity of information on the epidemiology of paediatric IBD in the Southern Hemisphere. The present study aimed to document the prospectively collected incidence of paediatric IBD in New Zealand in 2015.

METHODS

All patients younger than 16 years of age and diagnosed with IBD in New Zealand between 1 January 2015 and 31 December 2015 were identified. Demographic and disease phenotypic details were collected and entered into a secure database. Age-specific population data for New Zealand were obtained and national incidence rates for IBD and its subtypes were calculated.

RESULTS

The prospectively calculated incidence of paediatric IBD, Crohn disease, ulcerative colitis (UC), and IBD unclassified in New Zealand in 2015 were 5.2 (95% confidence interval 3.9-6.8), 3.5 (2.4-4.8), 1.0 (0.5-1.8), and 0.7 (0.3-1.4) per 100,000 children, respectively.

CONCLUSIONS

Incidence rates of paediatric IBD in New Zealand are comparable to the highest rates published in the literature from Western Europe and North America. Ongoing prospective ascertainment of the incidence of paediatric IBD is required to better understand the environmental factors, which are accounting for this increase in disease burden.

摘要

背景

儿童炎症性肠病(IBD)的全球发病率正在上升。证明这一点的许多证据来自北美和欧洲。关于南半球儿童IBD流行病学的信息相对较少。本研究旨在记录2015年新西兰前瞻性收集的儿童IBD发病率。

方法

确定了2015年1月1日至2015年12月31日期间在新西兰所有16岁以下诊断为IBD的患者。收集人口统计学和疾病表型细节并输入安全数据库。获取新西兰特定年龄的人口数据,并计算IBD及其亚型的全国发病率。

结果

2015年新西兰前瞻性计算的儿童IBD、克罗恩病、溃疡性结肠炎(UC)和未分类IBD的发病率分别为每10万名儿童5.2(95%置信区间3.9 - 6.8)、3.5(2.4 - 4.8)、1.0(0.5 - 1.8)和0.7(0.3 - 1.4)。

结论

新西兰儿童IBD的发病率与西欧和北美文献中公布的最高发病率相当。需要持续前瞻性确定儿童IBD的发病率,以更好地了解导致疾病负担增加的环境因素。

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