Nziza Nadege, Jung Wonyeong, Mendu Maanasa, Chen Tina, McNamara Ryan P, Fortune Sarah M, Franken Kees L M C, Ottenhoff Tom H M, Bryson Bryan, Ngonzi Joseph, Bebell Lisa M, Alter Galit
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.
Department of Molecular and Cellular Biology, Harvard University, Boston, MA, United States.
Front Microbiol. 2023 May 9;14:1171990. doi: 10.3389/fmicb.2023.1171990. eCollection 2023.
Placental transfer of maternal antibodies is essential for neonatal immunity over the first months of life. In the setting of maternal HIV infection, HIV-exposed uninfected (HEU) infants are at higher risk of developing severe infections, including active tuberculosis (TB). Given our emerging appreciation for the potential role of antibodies in the control of (), the bacteria that causes TB, here we aimed to determine whether maternal HIV status altered the quality of -specific placental antibody transfer.
Antigen-specific antibody systems serology was performed to comprehensively characterize the -specific humoral immune response in maternal and umbilical cord blood from HIV infected and uninfected pregnant people in Uganda.
Significant differences were noted in overall antibody profiles in HIV positive and negative maternal plasma, resulting in heterogeneous transfer of -specific antibodies. Altered antibody transfer in HIV infected dyads was associated with impaired binding to IgG Fc-receptors, which was directly linked to HIV viral loads and CD4 counts.
These results highlight the importance of maternal HIV status on antibody transfer, providing clues related to alterations in transferred maternal immunity that may render HEU infants more vulnerable to TB than their HIV-unexposed peers.
母体抗体的胎盘转运对于新生儿出生后最初几个月的免疫至关重要。在母体感染艾滋病毒的情况下，暴露于艾滋病毒但未感染（HEU）的婴儿发生包括活动性结核病（TB）在内的严重感染的风险更高。鉴于我们逐渐认识到抗体在控制导致结核病的（）中的潜在作用，我们在此旨在确定母体艾滋病毒感染状况是否会改变特异性胎盘抗体转运的质量。
采用抗原特异性抗体系统血清学方法，全面表征乌干达感染和未感染艾滋病毒的孕妇母体和脐带血中特异性体液免疫反应。
在艾滋病毒阳性和阴性母体血浆的总体抗体谱中发现了显著差异，导致特异性抗体的异质性转运。艾滋病毒感染的母婴对中抗体转运改变与与IgG Fc受体的结合受损有关，这与艾滋病毒病毒载量和CD4计数直接相关。
这些结果突出了母体艾滋病毒感染状况对抗体转运的重要性，提供了与母体转移免疫改变相关的线索，这些改变可能使HEU婴儿比未暴露于艾滋病毒的同龄人更容易患结核病。
需注意，原文中括号部分内容缺失，翻译可能存在一定局限性。
