Oncolytic viruses: Narcissistic or altruistic arsonists?
作者信息
Kendall Luke, Vile Richard G
机构信息
Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
出版信息
Mol Ther Oncolytics. 2023 Apr 26;29:42-43. doi: 10.1016/j.omto.2023.04.002. eCollection 2023 Jun 15.
Abstract
摘要
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Oncolytic virus-mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice.溶瘤病毒介导的双特异性 CAR T 细胞扩增可提高小鼠对抗实体瘤的疗效。
Sci Transl Med. 2022 Apr 13;14(640):eabn2231. doi: 10.1126/scitranslmed.abn2231.
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Robust Iterative Stimulation with Self-Antigens Overcomes CD8 T Cell Tolerance to Self- and Tumor Antigens.用自身抗原进行稳健的迭代刺激可克服 CD8 T 细胞对自身和肿瘤抗原的耐受。
Cell Rep. 2019 Sep 17;28(12):3092-3104.e5. doi: 10.1016/j.celrep.2019.08.038.
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Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy.病毒特异性记忆 T 细胞浸润肿瘤组织，并可被重新用于肿瘤免疫治疗。
Nat Commun. 2019 Feb 4;10(1):567. doi: 10.1038/s41467-019-08534-1.
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Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.预先存在的对溶瘤病毒的免疫增强了其免疫治疗效果。
Mol Ther. 2018 Apr 4;26(4):1008-1019. doi: 10.1016/j.ymthe.2018.01.019. Epub 2018 Jan 31.
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Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy.局部溶瘤病毒治疗克服了系统肿瘤对免疫检查点阻断免疫治疗的耐药性。
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