Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Med Sci Sports Exerc. 2023 Oct 1;55(10):1781-1791. doi: 10.1249/MSS.0000000000003205. Epub 2023 May 12.
The aim of this study was to understand the serum metabolomic signatures of moderate-to-vigorous physical activity (MVPA) and sedentary behavior, and further associate their metabolomic signatures with incident cardiometabolic diseases.
This analysis included 2711 US Hispanics/Latinos from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) aged 18-74 yr (2008-2011). An untargeted, liquid chromatography-mass spectrometry was used to profile the serum metabolome. The associations of metabolites with accelerometer-measured MVPA and sedentary time were examined using survey linear regressions adjusting for covariates. The weighted correlation network analysis identified modules of correlated metabolites in relation to sedentary time, and the modules were associated with incident diabetes, dyslipidemia, and hypertension over the 6-yr follow-up.
Of 624 metabolites, 5 and 102 were associated with MVPA and sedentary behavior at false discovery rate (FDR) <0.05, respectively, after adjusting for socioeconomic and lifestyle factors. The weighted correlation network analysis identified 8 modules from 102 metabolites associated with sedentary time. Four modules (branched-chain amino acids, erythritol, polyunsaturated fatty acid, creatine) were positively, and the other four (acyl choline, plasmalogen glycerol phosphatidyl choline, plasmalogen glycerol phosphatidyl ethanolamine, urea cycle) were negatively correlated with sedentary time. Among these modules, a higher branched-chain amino acid score and a lower plasmalogen glycerol phosphatidyl choline score were associated with increased risks of diabetes and dyslipidemia. A higher erythritol score was associated with an increased risk of diabetes, and a lower acyl choline score was linked to an increased risk of hypertension.
In this study of US Hispanics/Latinos, we identified multiple serum metabolomic signatures of sedentary behavior and their associations with risk of incident diabetes, hypertension, and dyslipidemia. These findings suggest a potential role of circulating metabolites in the links between sedentary behavior and cardiometabolic diseases.
本研究旨在了解中高强度体力活动（MVPA）和久坐行为的血清代谢组学特征，并进一步将其代谢组学特征与心血管代谢疾病的发病相关联。
本分析纳入了来自美国西班牙裔/拉丁裔的 2711 名 HCHS/SOL 参与者，年龄在 18-74 岁之间（2008-2011 年）。采用非靶向液相色谱-质谱联用技术对血清代谢组进行分析。采用调查线性回归法，在校正了协变量后，对代谢物与加速度计测量的 MVPA 和久坐时间的相关性进行了检验。基于与久坐时间相关的模块，采用加权相关网络分析识别相关代谢物模块，并在 6 年的随访中评估这些模块与新发糖尿病、血脂异常和高血压的相关性。
在 FDR<0.05 的水平下，有 5 种代谢物和 102 种代谢物与 MVPA 和久坐行为相关，这些代谢物在调整了社会经济和生活方式因素后得到了校正。基于与久坐时间相关的模块，采用加权相关网络分析共识别出 102 种代谢物的 8 个模块。其中，4 个模块（支链氨基酸、赤藓糖醇、多不饱和脂肪酸、肌酸）与久坐时间呈正相关，另外 4 个模块（酰基胆碱、甘油磷脂酰胆碱、甘油磷脂酰乙醇胺、尿素循环）与久坐时间呈负相关。在这些模块中，较高的支链氨基酸评分和较低的甘油磷脂酰胆碱评分与糖尿病和血脂异常风险增加相关。较高的赤藓糖醇评分与糖尿病风险增加相关，较低的酰基胆碱评分与高血压风险增加相关。
在这项针对美国西班牙裔/拉丁裔的研究中，我们发现了久坐行为的多个血清代谢组学特征及其与新发糖尿病、高血压和血脂异常风险的关联。这些发现提示循环代谢物可能在久坐行为与心血管代谢疾病之间的联系中发挥作用。
