Department of Veterinary Public Health, College of Veterinary Medicine, Shandong Agricultural University, Taian City, Shandong Province, China.
Binzhou Institute of Animal Husbandry and Veterinary Sciences, Binzhou, Shandong Province, China.
Res Vet Sci. 2023 Jun;159:232-236. doi: 10.1016/j.rvsc.2023.04.005. Epub 2023 Apr 15.
Avian encephalomyelitis (AE) is a highly infectious disease caused by the avian encephalomyelitis virus (AEV), which primarily affects the central nervous system of 1- to 4-week-old chicks and causes significant economic losses in the worldwide poultry industry. Despite heavy dependency on vaccine immunization, AEV has persisted on farms for extended periods, which increases its virulence and makes quick and accurate detection crucial to preventing and controlling the disease. Classical diagnostic methods have been unable to meet the current requirements for rapid diagnosis of AE cases. To address this issue, this paper reviews the etiological and molecular biological detection techniques of AE, and it seeks to provide a reference for future research and to establish differential diagnostic techniques for AE epidemiological investigation, identification of epidemic strains, and early diagnosis of clinical cases. Through improving our understanding of AE, we can better combat the disease and protect the global poultry industry.
禽流感（AE）是一种由禽脑脊髓炎病毒（AEV）引起的高度传染性疾病，主要影响 1 至 4 周龄小鸡的中枢神经系统，给全球家禽业造成了重大经济损失。尽管严重依赖疫苗免疫，但 AEV 在农场中持续存在了很长时间，这增加了其毒力，因此快速准确的检测对于预防和控制疾病至关重要。传统的诊断方法已经不能满足当前对 AE 病例快速诊断的要求。为了解决这个问题，本文综述了 AE 的病因学和分子生物学检测技术，旨在为未来的研究提供参考，并建立用于 AE 流行病学调查、流行株鉴定和临床病例早期诊断的鉴别诊断技术。通过提高我们对 AE 的认识，我们可以更好地对抗这种疾病，保护全球家禽业。
