Su W P, Greene S L
Am J Dermatopathol. 1986 Apr;8(2):144-7. doi: 10.1097/00000372-198604000-00009.
A deep sclerotic process developed on the shins of a 58-year-old man, and eosinophilic fasciitis or morphea profunda was suspected clinically. Bullae later arose on the plaques, and histologic examination of a skin biopsy specimen revealed sclerosis and inflammation of the deep dermis, panniculus, and fascia, with subepidermal edema causing formation of bullae. No lymphatic obstruction or vasculitis was seen. Two plaques of typical morphea on the penis were noticed 10 months later. The patient had no peripheral or tissue eosinophilia, hypergammaglobulinemia, hematologic abnormality, or history of exertion before the onset of the disease. The sclerotic process involved more than the fascia. In describing this deeper variant of morphea, the term "morphea profunda" appears to be more appropriate than "eosinophilic fasciitis."
一名58岁男性的胫部出现了一个深部硬化过程，临床怀疑为嗜酸性筋膜炎或深部硬斑病。随后斑块上出现大疱，皮肤活检标本的组织学检查显示真皮深层、皮下组织和筋膜有硬化及炎症，表皮下水肿导致大疱形成。未见淋巴管阻塞或血管炎。10个月后在阴茎上发现了两块典型的硬斑病斑块。患者在疾病发作前没有外周或组织嗜酸性粒细胞增多、高球蛋白血症、血液学异常或劳累史。硬化过程不仅累及筋膜。在描述这种深部硬斑病变体时，“深部硬斑病”一词似乎比“嗜酸性筋膜炎”更合适。
