从 var. 中分离得到的 7 种具有抗氧化活性的新苯己烷类化合物。

Seven New Phenylhexanoids with Antioxidant Activity from var. .

机构信息

West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

出版信息

Molecules. 2023 May 6;28(9):3928. doi: 10.3390/molecules28093928.

DOI:10.3390/molecules28093928

PMID:37175339

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10180102/

Abstract

Seven new phenylhexanoids, ()-(+)-3,4-dihydroxy-11-methoxyphenylhex-9-one (), () 3,4-dihydroxy-phenylhex-10-en-9-one (), ()-4-hydroxyphenylhex-10-en-9-one (), ()-(-)-3,4,11-trihydroxyphenylhex-9-one 11---d-glucopyranoside (), ()-(-)-4,11-dihydroxyphenylhex-9-one 11---d-glucopyranoside (), phenylhex-4,9,11-triol 11---d-glucopyranoside (), and 9--acetyl-phenylhex-4,9,11-triol 11---d-glucopyranoside (), were isolated and identified from Tibetan medicine var. . The antioxidant activities of these compounds were evaluated using the DPPH and ABTS radical scavenging experiments. In the ABTS experiment, compounds (IC 13.99 ± 2.53 μM) and (IC 13.11 ± 0.94 μM) exhibited significantly better antioxidant activity than L-ascorbic acid (IC 23.51 ± 0.44 μM).

摘要

从藏药 var. 中分离鉴定了 7 个新的苯己烷类化合物，()-(+)-3,4-二羟基-11-甲氧基苯基己-9-酮 ()、()3,4-二羟基-苯基己-10-烯-9-酮 ()、()-4-羟基苯基己-10-烯-9-酮 ()、()-(-)-3,4,11-三羟基苯基己-9-酮 11---d-吡喃葡萄糖苷 ()、()-(-)-4,11-二羟基苯基己-9-酮 11---d-吡喃葡萄糖苷 ()、苯己-4,9,11-三醇 11---d-吡喃葡萄糖苷 ()和 9--乙酰基-苯己-4,9,11-三醇 11---d-吡喃葡萄糖苷 ()。采用 DPPH 和 ABTS 自由基清除实验评价了这些化合物的抗氧化活性。在 ABTS 实验中，化合物 (IC 13.99 ± 2.53 μM) 和 (IC 13.11 ± 0.94 μM) 的抗氧化活性明显优于 L-抗坏血酸 (IC 23.51 ± 0.44 μM)。