Monoterpenoid Glycosides from the Leaves of and Their Bioactivities.

The leaves of have been applied as Ku-Ding-Cha, a functional tea to clear heat, remove toxins, and treat obesity and diabetes, in Southwest China. The phytochemical research on the leaves of led to the isolation and identification of eight new monoterpenoid glycosides (-) and three known monoterpenoid glycosides (-). Compounds - were tested for the inhibitory activities on fatty acid synthase (FAS), -glucosidase, -amylase, and the antioxidant effects. Compound showed stronger FAS inhibitory activity (IC: 2.36 ± 0.10 μM) than the positive control orlistat (IC: 4.46 ± 0.13 μM), while compounds , , and displayed more potent ABTS radical scavenging activity (IC: 6.91 ± 0.10~9.41 ± 0.22 μM) than the positive control L-(+)-ascorbic acid (IC: 10.06 ± 0.19 μM). This study provided a theoretical basis for the leaves of as a functional tea to treat obesity.