Mohammed Abdullah H, Kovacev Nikolina, Elshaer Amr, Melaibari Ammar A, Iqbal Javed, Hassanin Hany, Essa Khamis, Memić Adnan
School of Engineering, University of Birmingham, Birmingham B15 2TT, UK.
Center of Nanotechnology, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Polymers (Basel). 2023 May 8;15(9):2229. doi: 10.3390/polym15092229.
Fused Deposition Modelling (FDM) 3D printers have gained significant popularity in the pharmaceutical and biomedical industries. In this study, a new biomaterial filament was developed by preparing a polylactic acid (PLA)/calcium peroxide (CPO) composite using wet solution mixing and extrusion. The content of CPO varied from 3% to 24% wt., and hot-melt extruder parameters were optimised to fabricate 3D printable composite filaments. The filaments were characterised using an X-ray diffraction analysis, surface morphology assessment, evaluation of filament extrudability, microstructural analysis, and examination of their rheological and mechanical properties. Our findings indicate that increasing the CPO content resulted in increased viscosity at 200 °C, while the PLA/CPO samples showed microstructural changes from crystalline to amorphous. The mechanical strength and ductility of the composite filaments decreased except for in the 6% CPO filament. Due to its acceptable surface morphology and strength, the PLA/CPO filament with 6% CPO was selected for printability testing. The 3D-printed sample of a bone scaffold exhibited good printing quality, demonstrating the potential of the PLA/CPO filament as an improved biocompatible filament for FDM 3D printing.
熔融沉积建模（FDM）3D打印机在制药和生物医学行业中已获得显著的普及。在本研究中，通过使用湿溶液混合和挤出制备聚乳酸（PLA）/过氧化钙（CPO）复合材料，开发了一种新型生物材料长丝。CPO的含量从3%到24%重量不等，并优化了热熔挤出机参数以制造3D可打印复合长丝。使用X射线衍射分析、表面形态评估、长丝挤出性评估、微观结构分析以及流变学和力学性能检查对长丝进行了表征。我们的研究结果表明，CPO含量的增加导致200°C时粘度增加，而PLA/CPO样品显示出从结晶到无定形的微观结构变化。除了6% CPO长丝外，复合长丝的机械强度和延展性下降。由于其可接受的表面形态和强度，选择了含6% CPO的PLA/CPO长丝进行可打印性测试。骨支架的3D打印样品表现出良好的打印质量，证明了PLA/CPO长丝作为用于FDM 3D打印的改进生物相容性长丝的潜力。
