Beijing Institute of Radiation Medicine, Beijing, 100850, People's Republic of China.
J Physiol Biochem. 2023 Aug;79(3):489-500. doi: 10.1007/s13105-023-00966-0. Epub 2023 May 13.
A growing emphasis has been paid to the function of mitochondria in tumors, neurodegenerative disorders (NDs), and cardiovascular diseases. Mitochondria are oxygen-sensitive organelles whose function depends on their structural basis. Mitochondrial dynamics are critical in regulating the structure. Mitochondrial dynamics include fission, fusion, motility, cristae remodeling, and mitophagy. These processes could alter mitochondrial morphology, number, as well as distribution, to regulate complicated cellular signaling processes like metabolism. Meanwhile, they also could modulate cell proliferation and apoptosis. The initiation and progression of several diseases, such as tumors, NDs, cardiovascular disease, were all interrelated with mitochondrial dynamics. HIF-1 is a nuclear protein presented as heterodimers, and its transcriptional activity is triggered by hypoxia. It plays an important role in numerous physiological processes including the development of cardiovascular system, immune system, and cartilage. Additionally, it could evoke compensatory responses in cells during hypoxia through upstream and downstream signaling networks. Moreover, the alteration of oxygen level is a pivotal factor to promote mitochondrial dynamics and HIF-1 activation. HIF-1α might be a promising target for modulating mitochondrial dynamics to develop therapeutic approaches for NDs, immunological diseases, and other related diseases. Here, we reviewed the research progress of mitochondrial dynamics and the potential regulatory mechanism of HIF-1 in mitochondrial dynamics.
人们越来越关注线粒体在肿瘤、神经退行性疾病（NDs）和心血管疾病中的功能。线粒体是对氧敏感的细胞器，其功能取决于其结构基础。线粒体动力学对于调节结构至关重要。线粒体动力学包括裂变、融合、运动、嵴重塑和自噬。这些过程可以改变线粒体的形态、数量和分布，以调节代谢等复杂的细胞信号转导过程。同时，它们还可以调节细胞增殖和凋亡。几种疾病的发生和发展，如肿瘤、NDs、心血管疾病，都与线粒体动力学密切相关。HIF-1 是一种核蛋白，以异二聚体的形式存在，其转录活性由缺氧触发。它在许多生理过程中发挥着重要作用，包括心血管系统、免疫系统和软骨的发育。此外，它可以通过上游和下游信号网络在缺氧时在细胞中引发代偿性反应。此外，氧水平的改变是促进线粒体动力学和 HIF-1 激活的关键因素。HIF-1α 可能是调节线粒体动力学的一个有前途的靶点，可用于开发 NDs、免疫性疾病和其他相关疾病的治疗方法。在这里，我们综述了线粒体动力学的研究进展以及 HIF-1 在调节线粒体动力学中的潜在机制。
