Chair and Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, Poland.
Biomed Pharmacother. 2023 Jul;163:114853. doi: 10.1016/j.biopha.2023.114853. Epub 2023 May 11.
The hydrazones and hydrazide-hydrazones beside possessing crucial bioactivity can serve as useful intermediates in the synthesis of heterocyclic systems like 1,3-benzothiazin-4-one, 1,3-thiazolidin-4-one, azetidin-2-one and 1,3,4-oxadiazole derivatives. The azetidin-2-one derivatives show mainly antibacterial, antitubercular and antifungal activity as well as anti-inflammatory, antioxidant, anticonvulsant and antidepressant activity and activity against Parkinson's disease. This review is focused on the literature reports which consider the synthesis and biological properties of azetidin-2-one derivatives.
腙和腙衍生物除了具有重要的生物活性外，还可以作为合成杂环系统的有用中间体，如 1,3-苯并噻嗪-4-酮、1,3-噻唑烷-4-酮、氮杂环丁烷-2-酮和 1,3,4-噁二唑衍生物。氮杂环丁烷-2-酮衍生物主要表现出抗菌、抗结核和抗真菌活性，以及抗炎、抗氧化、抗惊厥和抗抑郁活性以及对抗帕金森病的活性。本综述重点关注考虑氮杂环丁烷-2-酮衍生物的合成和生物特性的文献报道。
