Pease C T, Charles P J, Shattles W, Markwick J, Maini R N
Department of Rheumatology, Charing Cross Hospital, London.
Br J Rheumatol. 1993 Jul;32(7):574-7. doi: 10.1093/rheumatology/32.7.574.
The clinical course of 48 patients with primary Sjögren's syndrome (primary SS) was reviewed. Forty-three north European patients were typed for HLA class I and class II alloantigens. In this population with primary SS HLA B8, DR3 and DRw52 all occurred more frequently than in the control population (P < 0.009, P < 0.0035, P < 0.02 respectively). The subgroup of primary SS patients with antibodies to Ro and/or La antigen had the greatest prevalence of DR3 (relative risk 33.4). The primary SS patients fall into two distinct groups: those with extraglandular disease in whom lymphopaenia, hypergammaglobulinaemia, antibodies to Ro and/or La and HLA DR3 were all more frequent and those patients with either glandular disease alone or only one extraglandular feature. There was no difference in disease duration between the two groups, although on average the latter group were 10 years older.
对48例原发性干燥综合征（原发性SS）患者的临床病程进行了回顾。对43例北欧患者进行了HLAⅠ类和Ⅱ类同种抗原分型。在这个原发性SS人群中，HLA B8、DR3和DRw52的出现频率均高于对照人群（P分别<0.009、<0.0035、<0.02）。具有抗Ro和/或La抗原抗体的原发性SS患者亚组中DR3的患病率最高（相对风险为33.4）。原发性SS患者分为两个不同的组：有腺外疾病的患者，其淋巴细胞减少、高球蛋白血症、抗Ro和/或La抗体以及HLA DR3更为常见；另一组是仅患有腺体疾病或只有一种腺外特征的患者。两组之间的病程没有差异，尽管后一组患者的平均年龄比前一组大10岁。
