Su Xin, Wang Li, Ma Ning, Yang Xinyu, Liu Can, Yang Fan, Li Jun, Yi Xin, Xing Yanwei
China Academy of Chinese Medical Sciences, Guang'anmen Hospital, Beijing, China.
Department of Breast Surgery, Xingtai People's Hospital, Xingtai, China.
Front Cardiovasc Med. 2023 Apr 25;10:1057870. doi: 10.3389/fcvm.2023.1057870. eCollection 2023.
A variety of immune cell subsets occupy different niches in the cardiovascular system, causing changes in the structure and function of the heart and vascular system, and driving the progress of cardiovascular diseases (CVDs). The immune cells infiltrating the injury site are highly diverse and integrate into a broad dynamic immune network that controls the dynamic changes of CVDs. Due to technical limitations, the effects and molecular mechanisms of these dynamic immune networks on CVDs have not been fully revealed. With recent advances in single-cell technologies such as single-cell RNA sequencing, systematic interrogation of the immune cell subsets is feasible and will provide insights into the way we understand the integrative behavior of immune populations. We no longer lightly ignore the role of individual cells, especially certain highly heterogeneous or rare subpopulations. We summarize the phenotypic diversity of immune cell subsets and their significance in three CVDs of atherosclerosis, myocardial ischemia and heart failure. We believe that such a review could enhance our understanding of how immune heterogeneity drives the progression of CVDs, help to elucidate the regulatory roles of immune cell subsets in disease, and thus guide the development of new immunotherapies.
多种免疫细胞亚群在心血管系统中占据不同的微环境，导致心脏和血管系统的结构与功能发生变化，并推动心血管疾病（CVDs）的进展。浸润损伤部位的免疫细胞高度多样化，并整合到一个广泛的动态免疫网络中，该网络控制着CVDs的动态变化。由于技术限制，这些动态免疫网络对CVDs的影响和分子机制尚未完全揭示。随着单细胞RNA测序等单细胞技术的最新进展，对免疫细胞亚群进行系统研究是可行的，这将为我们理解免疫群体的整合行为提供见解。我们不再轻易忽视单个细胞的作用，尤其是某些高度异质性或罕见的亚群。我们总结了免疫细胞亚群的表型多样性及其在动脉粥样硬化、心肌缺血和心力衰竭这三种CVDs中的意义。我们相信，这样的综述可以增强我们对免疫异质性如何驱动CVDs进展的理解，有助于阐明免疫细胞亚群在疾病中的调节作用，从而指导新免疫疗法的开发。
