Grom V V
Arkh Anat Gistol Embriol. 1986 Apr;90(4):55-9.
Nonsteroid antiinflammatory preparations, influencing biosynthesis of renal prostaglandins, are able to produce certain changes in hemodynamics of the organ with successive ischemia. Administration of these preparation (indomethacin and voltaren) to rats in doses corresponding to human therapeutic ones, produces dystrophic changes in the canalicular epithelium of the nephron and appearance of infiltrates in the interstitium and in the lamina propria of the renal calyxes mucous membrane. Intercellular edema and changes in configuration of the cells, decreasing electron density of hyaloplasm, swelled mitochondria, diluted cysterns of the Golgi complex and of the endoplasmic reticulum--are general regularities in ultrastructural reorganization of the cells in response to administration of the two preparations. These changes differ only in degree of their manifestation. As demonstrate the results, the pharmacologic depression of the prostaglandin synthesis causes decreased blood supply of the kidneys and successive depression of their functional state. This can be considered as risk factors of the renal complications under treatment with the nonsteroid antiinflammatory preparations.
非甾体抗炎制剂可影响肾前列腺素的生物合成，在器官连续缺血时能引起其血流动力学的某些改变。给大鼠按相当于人类治疗剂量给予这些制剂（消炎痛和扶他林），会导致肾单位小管上皮发生营养不良性改变，并在间质以及肾盏黏膜固有层出现浸润。细胞间水肿、细胞形态改变、透明质细胞质电子密度降低、线粒体肿胀、高尔基体和内质网的囊泡稀释，这些都是细胞对这两种制剂给药产生超微结构重组的一般规律。这些变化仅在表现程度上有所不同。结果表明，前列腺素合成的药理抑制会导致肾脏血液供应减少，继而使其功能状态降低。这可被视为使用非甾体抗炎制剂治疗时发生肾脏并发症的危险因素。
