Temple University, United States.
Temple University, United States.
Biol Psychol. 2024 Jan;185:108724. doi: 10.1016/j.biopsycho.2023.108724. Epub 2023 Nov 18.
Multiple previous studies show associations between history of and familial risk for depression and reward function. These previous studies have predominantly focused on neural activation during monetary tasks. Fewer studies of have examined functional connectivity and social reward tasks, particularly in offspring of mothers with depression. This study examined brain function in older children (aged 9-14 years) through both regional activation and functional connectivity during monetary (n = 103) and social reward (n = 115) tasks. Overall, our study failed to find significant differences between offspring of mothers with and without depression on monetary (65 offspring of mothers without and 38 offspring of mother with depression) and social reward (73 offspring of mothers without and 42 offspring of mother with depression) tasks on task activation and functional connectivity. We discuss possibilities for developmental timing of finding differences between offspring of mothers with and without depression on monetary and social reward tasks.
多项先前的研究表明抑郁病史和家族抑郁风险与奖励功能之间存在关联。这些先前的研究主要集中在货币任务期间的神经激活上。较少的研究检查了功能连接和社会奖励任务，特别是在患有抑郁症的母亲的后代中。这项研究通过货币任务（n=103）和社会奖励任务（n=115）期间的区域激活和功能连接，检查了年龄较大的儿童（9-14 岁）的大脑功能。总体而言，我们的研究未能发现母亲没有和有抑郁的后代在货币（65 名母亲没有抑郁的后代和 38 名母亲有抑郁的后代）和社会奖励（73 名母亲没有抑郁的后代和 42 名母亲有抑郁的后代）任务上的任务激活和功能连接方面存在显著差异。我们讨论了在货币和社会奖励任务中发现母亲没有和有抑郁的后代之间差异的发育时间的可能性。
