Singjie Leonard Christianto, Kusuma Samuel Andi, Saleh Ifran, Kholinne Erica
Bone and Joint Center, St. Carolus Hospital, Jakarta, Indonesia.
Atma Jaya Hospital, Jakarta, Indonesia.
Asian Spine J. 2023 Aug;17(4):782-789. doi: 10.31616/asj.2022.0209. Epub 2023 May 15.
Low back pain is one of the leading causes of disability in the world. Regenerative medicine can be one of the novel treatment breakthroughs in patients with low back pain, yet its use is still debatable. We performed a systematic evaluation and meta-analysis to determine the efficacy of platelet-rich plasma (PRP) treatment for patients with chronic low back pain. Comprehensive database searches were performed in four databases. This study was conducted and reported based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses Guideline and registered to PROSPERO. We included and examined randomized controlled trials that looked into research employing PRP for patients with chronic low back pain. Outcomes of interest include clinical enhancement of pain, which is demonstrated in pain scores. Three studies were included comprising 138 patients with chronic low back pain. After 1, 3, and 6 months after injection, there was a substantial reduction in the pain score difference between the PRP and control groups, demonstrating PRP's superiority over the control group in the treatment of chronic low back pain. PRP injection significantly enhances chronic low back pain in the first, third, and sixth months after injection compared to controls.
腰痛是全球导致残疾的主要原因之一。再生医学可能是腰痛患者新型治疗方法的突破之一，但其应用仍存在争议。我们进行了系统评价和荟萃分析，以确定富血小板血浆（PRP）治疗慢性腰痛患者的疗效。在四个数据库中进行了全面的数据库检索。本研究依据系统评价和荟萃分析的首选报告项目指南进行并报告，并在国际前瞻性系统评价注册库（PROSPERO）登记。我们纳入并审查了针对慢性腰痛患者采用PRP的随机对照试验。感兴趣的结果包括疼痛的临床改善，这在疼痛评分中得到体现。纳入了三项研究，共138例慢性腰痛患者。注射后1个月、3个月和6个月，PRP组与对照组之间的疼痛评分差异显著降低，表明PRP在治疗慢性腰痛方面优于对照组。与对照组相比，PRP注射在注射后的第1个月、第3个月和第6个月显著改善了慢性腰痛。
