Department of Orthopaedics, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopaedic Diseases, Liaoning Province, China.
Oxid Med Cell Longev. 2020 Nov 21;2020:8893819. doi: 10.1155/2020/8893819. eCollection 2020.
Intervertebral disc degeneration (IDD) is a globally occurring disease that represents a significant cause of socioeconomic problems. Currently, the main method for treating IDD is surgery, including discectomy and vertebral fusion. Several experiments demonstrated that platelet-rich plasma (PRP) could stimulate cell proliferation and extracellular matrix regeneration. Additionally, experiments have proven that PRP injection could restore intervertebral disc height. Clinical studies demonstrated that PRP injection could significantly relieve patient pain. However, further studies are still required to clarify the roles of PRP in IDD prevention and treatment. This review is aimed at summarizing and critically analyzing the current evidence regarding IDD treatment with PRP.
椎间盘退变（IDD）是一种全球范围内发生的疾病，是造成重大社会经济问题的主要原因之一。目前，治疗 IDD 的主要方法是手术，包括椎间盘切除术和椎体融合术。多项实验表明，富血小板血浆（PRP）可刺激细胞增殖和细胞外基质再生。此外，实验已经证明 PRP 注射可以恢复椎间盘高度。临床研究表明，PRP 注射可显著缓解患者的疼痛。然而，仍需要进一步的研究来阐明 PRP 在 IDD 预防和治疗中的作用。本综述旨在总结和批判性分析目前关于 PRP 治疗 IDD 的证据。
