Department of Nutritional Sciences, Auburn University, Auburn, AL, USA.
College of Science and Mathematics, Auburn University, Auburn, AL, USA.
Nutr Neurosci. 2024 May;27(5):451-459. doi: 10.1080/1028415X.2023.2213484. Epub 2023 May 15.
To investigate the gut-brain axis, we explored the relationships among mood disturbance (MD), diet quality (DQ), and fecal microbiota in free-living adults.
A cross-sectional analysis was conducted with data from 75 healthy adults enrolled in two studies. Anthropometrics, 16s rRNA gene sequencing of fecal microbes, DQ as assessed by Healthy Eating Index-2015 (HEI), and MD determined by Profile of Mood States (POMS) were included. Alpha-diversity and DQ differences were explored between low ( = 37) and high MD ( = 38) groups. Spearman correlations were used to investigate relationships between alpha-diversity, DQ, and POMS subscales. Moderation analysis explored the effect of HEI score on the relationship between MD and alpha-diversity.
Participants were mostly white (67%), 54.5 years old (±11.8), and overweight (28.5 ± 6.5 kg/m). Shannon and Simpson indices indicate higher alpha-diversity in participants with low MD compared to high MD ( = 0.004 and = 0.008, respectively). Simpson and Shannon indices were correlated with subscale of anger (rho = -0.303, = 0.011; rho = -0.265, = 0.027, respectively)and total MD (rho = -0.404, = 0.001; rho = -0.357, = 0.002, respectively). Refined grains were associated with fatigue and tension subscales (rho = 0.428, <0.001; rho = 0.302, = 0.014, respectively). DQ did not significantly moderate the relationship between alpha-diversity and mood disturbance ((7, 53) = 2.00, = 0.072, = 0.209). Shannon index was a significant predictor of MD ( = -4.39, (53) = -2.55, = 0.014), but total HEI score and the interaction (Shannon index*HEI score) were not significant.
Greater bacterial diversity was associated with lower MD, and DQ was associated with various mood state subscales in this sample of adults.
为了研究肠道-大脑轴，我们探索了情绪障碍（MD）、饮食质量（DQ）和自由生活成年人粪便微生物群之间的关系。
对两项研究中招募的 75 名健康成年人的数据进行了横断面分析。包括人体测量学、粪便微生物 16s rRNA 基因测序、通过健康饮食指数-2015（HEI）评估的 DQ 以及通过心境状态量表（POMS）确定的 MD。在 MD 较低（ = 37）和较高（ = 38）组之间探索了 alpha 多样性和 DQ 差异。Spearman 相关性用于研究 alpha 多样性、DQ 和 POMS 子量表之间的关系。调节分析探索了 HEI 评分对 MD 和 alpha 多样性之间关系的影响。
参与者主要为白人（67%），年龄为 54.5 岁（±11.8），体重超重（28.5 ± 6.5 kg/m）。Shannon 和 Simpson 指数表明，与 MD 较高的参与者相比，MD 较低的参与者具有更高的 alpha 多样性（ = 0.004 和 = 0.008）。Simpson 和 Shannon 指数与愤怒子量表（rho = -0.303， = 0.011；rho = -0.265， = 0.027，分别）和总 MD（rho = -0.404， = 0.001；rho = -0.357， = 0.002，分别）呈负相关。精制谷物与疲劳和紧张子量表有关（rho = 0.428， <0.001；rho = 0.302， = 0.014，分别）。DQ 并没有显著调节 alpha 多样性和情绪障碍之间的关系（（7, 53） = 2.00， = 0.072， = 0.209）。Shannon 指数是 MD 的一个显著预测因子（ = -4.39，（53） = -2.55， = 0.014），但总 HEI 评分和交互作用（Shannon 指数*HEI 评分）并不显著。
在这个成年人样本中，更高的细菌多样性与更低的 MD 相关，DQ 与各种情绪状态子量表相关。
