小鼠椎间盘蛋白聚糖合成随年龄的变化。遗传性脊柱后凸侧弯与合成增加有关。
Changes in mouse intervertebral-disc proteoglycan synthesis with age. Hereditary kyphoscoliosis is associated with elevated synthesis.
作者信息
Venn G, Mason R M
出版信息
Biochem J. 1986 Mar 1;234(2):475-9. doi: 10.1042/bj2340475.
Abstract
Mice with hereditary kyphoscoliosis (ky/ky) develop intervertebral-disc degeneration at the cervico-thoracic junction. Disc proteoglycans were investigated to determine whether changes in synthesis or structure were associated with this. Elevated 35S-proteoglycan synthesis was found in one or more cervico-thoracic discs in 80-day-old ky/ky mice. The hydrodynamic size and aggregation properties of ky/ky-mouse disc 35S-proteoglycans extracted with 4 M-guanidinium chloride were normal. Increased proportions of small 35S-proteoglycans were extracted with 0.5 M-guanidinium chloride from discs of normal and ky/ky mice with increasing age.
摘要
患有遗传性脊柱后凸侧弯（ky/ky）的小鼠在颈胸交界处会发生椎间盘退变。对椎间盘蛋白聚糖进行了研究，以确定合成或结构的变化是否与此相关。在80日龄的ky/ky小鼠的一个或多个颈胸椎间盘内，发现35S-蛋白聚糖合成增加。用4M-氯化胍提取的ky/ky小鼠椎间盘35S-蛋白聚糖的流体动力学大小和聚集特性正常。随着年龄的增长，用0.5M-氯化胍从正常和ky/ky小鼠的椎间盘中提取的小35S-蛋白聚糖的比例增加。
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