Department of Endocrinology-Diabetology and Nutrition, Mohammed Vi University Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed First, Oujda, Morocco.
Laboratory of Epidemiology, Clinical Research and Public Health, Faculty of Medicine and Pharmacy, University of Mohammed First, Oujda, Morocco.
Rev Diabet Stud. 2023 Mar 31;19(1):1-7. doi: 10.1900/RDS.2023.19.1.
Type 1 diabetes mellitus (T1DM) incidence is currently increasing worldwide, and different environmental players along with genetic predisposition, could be involved as powerful triggers of this disease onset. In this study, we aim to shed the light on the relationship between 25OHD deficiency and T1DM. A case-control study was laid out to compare serum 25OHD level between T1DM patients and controls. A total of 147 T1DM patients aged under 19 years old were recruited from our Endocrinology-Diabetology and Nutrition department between October 2014 and December 2019. A total of 147 controls were randomly enlisted from clinical biochemistry laboratory of our center, and were carefully matched. The levels of 25OHD in the serum were determined in T1DM patients and nondiabetic controls. Average serum 25OHD concentration was established in both groups; reaching 19,29 ±6,13 ng/ml in the control arm and 15,02 ± 6,48 ng/ml in the selected group with T1DM independently of the disease duration. However, the mean serum 25OHD concentration was not significantly different between the two T1DM subgroups according to diabetes duration below or above 5 years, and 25OHD concentration remained lower either in winter or summer months. A negative correlation was noticed between HbA1c and serum 25 OHD concentration in T1DM patients and was statistically significant (p<0,05). Key messages on the importance of vitamin D status, particularly in diabetic children and adolescents, should be spread widely in order to start a suitable vitamin supplementation, and establish guidelines regarding its timing at adequate recommended doses..
1 型糖尿病（T1DM）的发病率目前在全球范围内呈上升趋势，不同的环境因素以及遗传易感性可能是这种疾病发病的强大诱因。在这项研究中，我们旨在阐明 25OHD 缺乏与 T1DM 之间的关系。我们进行了一项病例对照研究，比较了 T1DM 患者和对照组之间的血清 25OHD 水平。我们从内分泌学-糖尿病和营养科招募了 147 名年龄在 19 岁以下的 T1DM 患者，这些患者是在 2014 年 10 月至 2019 年 12 月期间确诊的。我们从中心的临床生化实验室随机招募了 147 名对照组，并进行了仔细匹配。测定了 T1DM 患者和非糖尿病对照组的血清 25OHD 水平。两组的平均血清 25OHD 浓度分别为对照组为 19.29 ± 6.13ng/ml，T1DM 组为 15.02 ± 6.48ng/ml，与疾病持续时间无关。然而，根据糖尿病持续时间（5 年以下或 5 年以上），两组 T1DM 亚组之间的平均血清 25OHD 浓度没有显著差异，冬季或夏季血清 25OHD 浓度仍然较低。T1DM 患者的 HbA1c 与血清 25OHD 浓度呈负相关，且具有统计学意义（p<0.05）。应广泛传播有关维生素 D 状态重要性的信息，特别是在糖尿病儿童和青少年中，以开始适当的维生素补充，并制定关于在适当推荐剂量下补充维生素的时间的指南。
