Department of Biomedical Engineering, College of Life Science and Biotechnology, Dongguk University, Seoul 04620, Republic of Korea.
Biosensors (Basel). 2023 Apr 11;13(4):470. doi: 10.3390/bios13040470.
Researchers are interested in measuring mental stress because it is linked to a variety of diseases. Real-time stress monitoring via wearable sensor systems can aid in the prevention of stress-related diseases by allowing stressors to be controlled immediately. Physical tests, such as heart rate or skin conductance, have recently been used to assess stress; however, these methods are easily influenced by daily life activities. As a result, for more accurate stress monitoring, validations requiring two or more stress-related biomarkers are demanded. In this review, the combinations of various types of sensors (hereafter referred to as multiplexed sensor systems) that can be applied to monitor stress are discussed, referring to physical and chemical biomarkers. Multiplexed sensor systems are classified as multiplexed physical sensors, multiplexed physical-chemical sensors, and multiplexed chemical sensors, with the effect of measuring multiple biomarkers and the ability to measure stress being the most important. The working principles of multiplexed sensor systems are subdivided, with advantages in measuring multiple biomarkers. Furthermore, stress-related chemical biomarkers are still limited to cortisol; however, we believe that by developing multiplexed sensor systems, it will be possible to explore new stress-related chemical biomarkers by confirming their correlations to cortisol. As a result, the potential for further development of multiplexed sensor systems, such as the development of wearable electronics for mental health management, is highlighted in this review.
研究人员对测量心理压力很感兴趣，因为它与多种疾病有关。通过可穿戴传感器系统进行实时压力监测，可以通过立即控制压力源来帮助预防与压力相关的疾病。心率或皮肤电导率等生理测试最近已被用于评估压力；然而，这些方法很容易受到日常生活活动的影响。因此，为了进行更准确的压力监测，需要对两种或更多种与压力相关的生物标志物进行验证。在这篇综述中，讨论了可应用于监测压力的各种类型传感器（以下简称多复用传感器系统）的组合，同时还参考了物理和化学生物标志物。多复用传感器系统分为多复用物理传感器、多复用物理化学传感器和多复用化学传感器，测量多个生物标志物的效果和测量压力的能力是最重要的。多复用传感器系统的工作原理进行了细分，具有测量多个生物标志物的优势。此外，与压力相关的化学生物标志物仍然仅限于皮质醇；然而，我们相信通过开发多复用传感器系统，可以通过确认它们与皮质醇的相关性来探索新的与压力相关的化学生物标志物。因此，本文强调了多复用传感器系统的进一步发展潜力，例如开发用于心理健康管理的可穿戴电子设备。
