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一种预测建模方法,用于说明与 12-23 个月龄儿童发育迟缓相关的因素:一项整群随机前后研究。

A predictive modelling approach to illustrate factors correlating with stunting among children aged 12-23 months: a cluster randomised pre-post study.

机构信息

Nutrition and Clinical Services Division, icddr,b, Dhaka, Bangladesh

Nutrition and Clinical Services Division, icddr,b, Dhaka, Bangladesh.

出版信息

BMJ Open. 2023 Apr 26;13(4):e067961. doi: 10.1136/bmjopen-2022-067961.

Abstract

OBJECTIVE

The aim of this study was to construct a predictive model in order to develop an intervention study to reduce the prevalence of stunting among children aged 12-23 months.

DESIGN

The study followed a cluster randomised pre-post design and measured the impacts on various indicators of livelihood, health and nutrition. The study was based on a large dataset collected from two cross-sectional studies (baseline and endline).

SETTING

The study was conducted in the north-eastern region of Bangladesh under the Sylhet division, which is vulnerable to both natural disasters and poverty. The study specifically targeted children between the ages of 12 and 23 months.

MAIN OUTCOME MEASURES

Childhood stunting, defined as a length-for-age z-score <-2, was the outcome variable in this study. Logistic and probit regression models and a decision tree were constructed to predict the factors associated with childhood stunting. The predictive performance of the models was evaluated by computing the area under the receiver operating characteristic (ROC) curve analysis.

RESULTS

The baseline survey showed a prevalence of 52.7% stunting, while 50.0% were stunted at endline. Several factors were found to be associated with childhood stunting. The model's sensitivity was 61% and specificity was 56%, with a correctly classified rate of 59% and an area under the ROC curve of 0.615.

CONCLUSION

The study found that childhood stunting in the study area was correlated with several factors, including maternal nutrition and education, food insecurity and hygiene practices. Despite efforts to address these factors, they remain largely unchanged. The study suggests that a more effective approach may be developed in future to target adolescent mothers, as maternal nutrition and education are age-dependent variables. Policy makers and programme planners need to consider incorporating both nutrition-sensitive and nutrition-specific activities and enhancing collaboration in their efforts to improve the health of vulnerable rural populations.

TRIAL REGISTRATION NUMBER

RIDIE-STUDY-ID-5d5678361809b.

摘要

目的

本研究旨在构建一个预测模型,以便开展干预研究,降低 12-23 月龄儿童发育迟缓的患病率。

设计

本研究采用整群随机前后测设计,测量了对各种生计、健康和营养指标的影响。研究基于从两项横断面研究(基线和终线)中收集的大型数据集。

地点

本研究在孟加拉国东北部的锡尔赫特分区进行,该地区易受自然灾害和贫困的影响。研究对象为 12-23 月龄的儿童。

主要结局指标

本研究的结局变量是儿童发育迟缓,定义为年龄别身长 z 评分<-2。构建了逻辑回归和概率回归模型以及决策树,以预测与儿童发育迟缓相关的因素。通过计算受试者工作特征(ROC)曲线分析的曲线下面积来评估模型的预测性能。

结果

基线调查显示,发育迟缓的患病率为 52.7%,而终线时为 50.0%。研究发现,有几个因素与儿童发育迟缓有关。模型的敏感性为 61%,特异性为 56%,正确分类率为 59%,ROC 曲线下面积为 0.615。

结论

本研究发现,研究区域的儿童发育迟缓与几个因素有关,包括母婴营养和教育、粮食不安全和卫生习惯。尽管努力解决这些因素,但它们基本没有变化。研究表明,未来可能需要制定更有效的方法来针对青少年母亲,因为母婴营养和教育是年龄相关的变量。决策者和规划者需要考虑将营养敏感和营养特定的活动结合起来,并加强合作,以改善弱势农村人口的健康状况。

试验注册号

RIDIE-STUDY-ID-5d5678361809b。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1d/10151845/6a21ef9c5831/bmjopen-2022-067961f01.jpg

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