氧化平衡评分与认知功能的关联及氧化应激的中介作用：来自2011 - 2014年美国国家健康与营养检查调查（NHANES）的证据
Association of the Oxidative Balance Score and Cognitive Function and the Mediating Role of Oxidative Stress: Evidence from the National Health and Nutrition Examination Survey (NHANES) 2011-2014.
作者信息
Song Lingling, Li Huiru, Fu Xihang, Cen Manqiu, Wu Jing
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
J Nutr. 2023 Jul;153(7):1974-1983. doi: 10.1016/j.tjnut.2023.05.014. Epub 2023 May 13.
BACKGROUND
Oxidative stress is possibly related to cognitive function decline. The oxidative balance score (OBS) that combines pro- and antioxidant components from diet and lifestyle has been reported to be associated with age-related diseases.
OBJECTIVES
We aimed to investigate the association between OBS and cognitive function in older adults and explore whether oxidative stress mediated this relationship.
METHODS
A total of 1745 adults aged ≥60 y were included in the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Cognitive function was measured using 4 tests: the immediate recall test, delayed recall test, animal fluency test (AFT), and digital symbol substitution test (DSST). Weighted multivariate linear regression and restricted cubic splines (RCS) analyses were used to evaluate the association between OBS and cognitive function, and mediation analysis was used to test the indirect effect of oxidative stress indicators on the association.
RESULTS
The OBS was positively associated with AFT, DSST, and global cognitive function in older adults, and the beta estimates (95% CI) were 0.015 (0.008, 0.034), 0.009 (0.002, 0.025), and 0.030 (0.024, 0.074), moreover, RCS results suggested an approximately linear dose-response relationship between the OBS and these 3 tests. The highest quartiles of these 3 tests were also significantly correlated with OBS. Albumin, uric acid, and serum 25(OH)D concentrations were significant mediators of the relationship between OBS and cognitive function, and the overall mediation effect proportion was 36% when included in 1 model.
CONCLUSIONS
OBS was positively correlated with cognitive function in older adults, and albumin, uric acid, and serum 25(OH)D concentrations could be the driving mediators of the association. The findings emphasize the importance of a healthy, antioxidant diet and lifestyle that contribute to cognitive function. J Nutr 20xx;x:xx.
背景
氧化应激可能与认知功能衰退有关。据报道，结合饮食和生活方式中促氧化和抗氧化成分的氧化平衡评分（OBS）与年龄相关疾病有关。
目的
我们旨在研究老年人OBS与认知功能之间的关联，并探讨氧化应激是否介导了这种关系。
方法
2011 - 2014年美国国家健康与营养检查调查（NHANES）纳入了总共1745名年龄≥60岁的成年人。使用4项测试测量认知功能：即时回忆测试、延迟回忆测试、动物流畅性测试（AFT）和数字符号替换测试（DSST）。采用加权多元线性回归和受限立方样条（RCS）分析来评估OBS与认知功能之间的关联，并使用中介分析来检验氧化应激指标对该关联的间接效应。
结果
OBS与老年人的AFT、DSST和整体认知功能呈正相关，β估计值（95%CI）分别为0.015（0.008，0.034）、0.009（0.002，0.025）和0.030（0.024，0.074），此外，RCS结果表明OBS与这3项测试之间存在近似线性剂量反应关系。这3项测试的最高四分位数也与OBS显著相关。白蛋白、尿酸和血清25(OH)D浓度是OBS与认知功能之间关系的显著中介因素，当纳入1个模型时，总体中介效应比例为36%。
结论
OBS与老年人的认知功能呈正相关，白蛋白、尿酸和血清25(OH)D浓度可能是这种关联的驱动中介因素。这些发现强调了有助于认知功能的健康、抗氧化饮食和生活方式的重要性。《营养学杂志》20xx年；x：xx。
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